Your Input: | |
| | WRN | WRN RecQ like helicase. (1462 aa) |
| | CTC1 | CST telomere replication complex component 1. (1206 aa) |
| | PRIM2 | DNA primase subunit 2. (432 aa) |
| | CENPN | Centromere protein N. (345 aa) |
| | Lig1 | DNA ligase. (909 aa) |
| | RFC1 | Replication factor C subunit 1. (1153 aa) |
| | Hjurp | Uncharacterized protein. (696 aa) |
| | RSF1 | Remodeling and spacing factor 1. (1433 aa) |
| | CENPO | Centromere protein O. (297 aa) |
| | LOC100731490 | Uncharacterized protein. (740 aa) |
| | CENPK | Centromere protein K. (268 aa) |
| | Pold3 | Uncharacterized protein. (466 aa) |
| | PPP6R3 | Protein phosphatase 6 regulatory subunit 3. (872 aa) |
| | RBPMS2 | RNA binding protein, mRNA processing factor 2. (178 aa) |
| | ATRX | ATRX chromatin remodeler. (2481 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (463 aa) |
| | CENPQ | Centromere protein Q. (264 aa) |
| | RFC3 | Replication factor C subunit 3. (220 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (513 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | CENPP | Centromere protein P. (283 aa) |
| | CENPT | Centromere protein T. (497 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | BLM | BLM RecQ like helicase. (1405 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (409 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (619 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (988 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (429 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (421 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | SHQ1 | SHQ1, H/ACA ribonucleoprotein assembly factor. (585 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | CENPM | Centromere protein M. (180 aa) |
| | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1056 aa) |
| | PPP6R2 | Protein phosphatase 6 regulatory subunit 2. (942 aa) |
| | Rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1246 aa) |
| | LOC100735848 | TINF2_N domain-containing protein. (416 aa) |
| | H0VSI3_CAVPO | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa) |
| | Rbbp4 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1018 aa) |
| | RECQL4 | RecQ like helicase 4. (1226 aa) |
| | Prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | MIS18A | MIS18 kinetochore protein A. (243 aa) |
| | LOC100728920 | Histone domain-containing protein; Belongs to the histone H2B family. (128 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | H2AJ | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | ENSCPOP00000026646 | annotation not available (126 aa) |
| | ENSCPOP00000026400 | annotation not available (125 aa) |
| | ENSCPOP00000026334 | WD_REPEATS_REGION domain-containing protein. (385 aa) |
| | DAXX | Death domain associated protein. (756 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | LOC100713990 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CENPS | Centromere protein S. (135 aa) |
| | HIST2H2AA3 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | ENSCPOP00000025561 | Histone H2A; Belongs to the histone H2A family. (72 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa) |
| | PPP6C | Serine/threonine-protein phosphatase. (305 aa) |
| | ANKRD66 | Ankyrin repeat domain 66. (225 aa) |
| | LOC100728325 | annotation not available (103 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCPOP00000024383 | annotation not available (126 aa) |
| | HIST2H2BE | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCPOP00000024347 | annotation not available (103 aa) |
| | ENSCPOP00000024311 | annotation not available (126 aa) |
| | LOC100733876 | annotation not available (103 aa) |
| | CENPU | Centromere protein U. (405 aa) |
| | ENSCPOP00000023894 | annotation not available (126 aa) |
| | LOC100717510 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Cenpx | Uncharacterized protein. (79 aa) |
| | NOP10 | NOP10 ribonucleoprotein. (64 aa) |
| | CENPW | Centromere protein W. (88 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1021 aa) |
| | Pold4 | Uncharacterized protein. (107 aa) |
| | LOC100735546 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC111756489 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | Trub1 | TruB_N domain-containing protein. (244 aa) |
| | POLD1 | DNA polymerase. (1134 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (420 aa) |
| | LOC100722162 | Histone H2A; Belongs to the histone H2A family. (111 aa) |
| | LOC100724929 | Histone H2A; Belongs to the histone H2A family. (117 aa) |
| | H2AZ1 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (486 aa) |
| | LOC100735042 | Histone domain-containing protein; Belongs to the histone H2B family. (125 aa) |
| | LOC111756490 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | H0W6R4_CAVPO | WD_REPEATS_REGION domain-containing protein. (418 aa) |
| | ENSCPOP00000026982 | annotation not available (130 aa) |
| | ANKRD44 | Ankyrin repeat domain 44. (997 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | OIP5 | Opa interacting protein 5. (234 aa) |
| | TERF2IP | TERF2 interacting protein. (371 aa) |
| | Pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | CENPC | Centromere protein C. (942 aa) |
| | POLA1 | DNA polymerase. (1467 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1051 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (541 aa) |
| | LOC100731150 | annotation not available (103 aa) |
| | ENSCPOP00000032251 | annotation not available (130 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | KNL1 | Kinetochore scaffold 1. (2185 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | LOC106027456 | annotation not available (126 aa) |
| | ENSCPOP00000030815 | CAF1C_H4-bd domain-containing protein. (54 aa) |
| | POT1 | Protection of telomeres 1. (652 aa) |
| | ENSCPOP00000030090 | annotation not available (126 aa) |
| | ANKRD28 | Ankyrin repeat domain 28. (1085 aa) |
| | ITGB3BP | Integrin subunit beta 3 binding protein. (198 aa) |
| | CENPH | Centromere protein H. (277 aa) |
| | ENSCPOP00000029297 | annotation not available (103 aa) |
| | ENSCPOP00000029061 | annotation not available (126 aa) |
| | CENPA | Centromere protein A. (131 aa) |
| | LOC100712757 | TINF2_N domain-containing protein. (397 aa) |
| | CENPL | Centromere protein L. (346 aa) |
| | NHP2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa) |
| | Ten1 | Uncharacterized protein. (122 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | ENSCPOP00000027781 | TruB_N domain-containing protein. (257 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | MIS18BP1 | MIS18 binding protein 1. (1127 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (222 aa) |
