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| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | USP21 | Ubiquitin specific peptidase 21; Belongs to the peptidase C19 family. (570 aa) |
| | TGM6 | Transglutaminase 6. (706 aa) |
| | H0VT19_CAVPO | TGc domain-containing protein. (700 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (665 aa) |
| | NCSTN | Nicastrin. (709 aa) |
| | NET1 | Neuroepithelial cell transforming 1. (597 aa) |
| | PRDM4 | RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. (1310 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (901 aa) |
| | SPPL2A | Signal peptide peptidase like 2A. (546 aa) |
| | NSMAF | Neutral sphingomyelinase activation associated factor. (900 aa) |
| | TIAM1 | T cell lymphoma invasion and metastasis 1. (1590 aa) |
| | MADD | MAP kinase activating death domain. (1627 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (383 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | ARHGEF40 | Rho guanine nucleotide exchange factor 40. (1518 aa) |
| | BAG4 | BCL2 associated athanogene 4. (456 aa) |
| | Casp3 | CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (165 aa) |
| | KALRN | Kalirin RhoGEF kinase. (2964 aa) |
| | MAG | Myelin associated glycoprotein. (592 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (349 aa) |
| | CLIP3 | CAP-Gly domain containing linker protein 3. (547 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (826 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (206 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | TRADD | TNFRSF1A associated via death domain. (310 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (789 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (753 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (739 aa) |
| | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (765 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1496 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (615 aa) |
| | USP4 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (965 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa) |
| | ULK2 | Unc-51 like autophagy activating kinase 2. (1033 aa) |
| | TIAM2 | T cell lymphoma invasion and metastasis 2. (1697 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | LINGO2 | Leucine rich repeat and Ig domain containing 2. (606 aa) |
| | RACK1 | Receptor for activated C kinase 1. (317 aa) |
| | OTULINL | OTU deubiquitinase with linear linkage specificity like. (284 aa) |
| | CLIP4 | CAP-Gly domain containing linker protein family member 4. (703 aa) |
| | H0VBD1_CAVPO | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (105 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (967 aa) |
| | ARHGEF26 | Rho guanine nucleotide exchange factor 26. (654 aa) |
| | ECT2L | Epithelial cell transforming 2 like. (948 aa) |
| | OPTN | Optineurin. (576 aa) |
| | LOC100731744 | NACHT domain-containing protein. (1402 aa) |
| | APH1A | Aph-1 homolog A, gamma-secretase subunit. (265 aa) |
| | RIPK2 | Receptor interacting serine/threonine kinase 2. (442 aa) |
| | AATF | Apoptosis antagonizing transcription factor. (568 aa) |
| | Rps27a | Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa) |
| | Bad | Uncharacterized protein. (166 aa) |
| | ARHGEF5 | Rho guanine nucleotide exchange factor 5. (1597 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | APH1B | Aph-1 homolog B, gamma-secretase subunit. (257 aa) |
| | ECT2 | Epithelial cell transforming 2. (913 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa) |
| | ARHGEF4 | Rho guanine nucleotide exchange factor 4. (486 aa) |
| | MCF2 | MCF.2 cell line derived transforming sequence. (1033 aa) |
| | ARHGEF11 | Rho guanine nucleotide exchange factor 11. (1494 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (430 aa) |
| | ARHGEF37 | Rho guanine nucleotide exchange factor 37. (671 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | LINGO1 | Leucine rich repeat and Ig domain containing 1. (620 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa) |
| | OTUD7B | OTU deubiquitinase 7B. (842 aa) |
| | FGD2 | FYVE, RhoGEF and PH domain containing 2. (627 aa) |
| | ARHGEF3 | Rho guanine nucleotide exchange factor 3. (558 aa) |
| | TAX1BP1 | Tax1 binding protein 1. (806 aa) |
| | ITSN1 | Intersectin 1. (1657 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (779 aa) |
| | ARHGEF39 | Rho guanine nucleotide exchange factor 39. (331 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (442 aa) |
| | OMG | Oligodendrocyte myelin glycoprotein. (443 aa) |
| | ENSCPOP00000033096 | DH domain-containing protein. (302 aa) |
| | ARHGEF17 | Rho guanine nucleotide exchange factor 17. (1815 aa) |
| | FGD4 | FYVE, RhoGEF and PH domain containing 4. (904 aa) |
| | ENSCPOP00000032781 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | BEX3 | Brain expressed X-linked 3. (111 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (707 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (749 aa) |
| | ARHGDIA | Rho GDP-dissociation inhibitor 1; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. T [...] (204 aa) |
| | Ubc | Uncharacterized protein. (159 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (656 aa) |
| | ENSCPOP00000031692 | CRAL-TRIO domain-containing protein. (645 aa) |
| | ENSCPOP00000031632 | Ubiquitin-like domain-containing protein. (141 aa) |
| | PLEKHG2 | Pleckstrin homology and RhoGEF domain containing G2. (1359 aa) |
| | Faslg | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa) |
| | Arhgef1 | RGS-like domain-containing protein. (102 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (293 aa) |
| | Ube2l3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | FAS | Fas cell surface death receptor. (334 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (711 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa) |
| | SPPL2C | Signal peptide peptidase like 2C. (669 aa) |
| | ENSCPOP00000030352 | Uncharacterized protein. (97 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (481 aa) |
| | ENSCPOP00000030285 | Uncharacterized protein. (1035 aa) |
| | ENSCPOP00000030204 | Uncharacterized protein. (150 aa) |
| | PLEKHG5 | Pleckstrin homology and RhoGEF domain containing G5. (1051 aa) |
| | UBB | Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | ITGB3BP | Integrin subunit beta 3 binding protein. (198 aa) |
| | Ywhae | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa) |
| | WDR31 | WD repeat domain 31. (366 aa) |
| | RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (513 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (469 aa) |
| | PSENEN | Presenilin enhancer, gamma-secretase subunit. (101 aa) |
| | NGEF | Neuronal guanine nucleotide exchange factor. (705 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (611 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (1037 aa) |
| | ARHGEF10L | Rho guanine nucleotide exchange factor 10 like. (1278 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | UBE2D3 | Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (140 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | ABR | ABR activator of RhoGEF and GTPase. (859 aa) |
| | ARHGEF15 | Rho guanine nucleotide exchange factor 15. (838 aa) |
| | FGD3 | FYVE, RhoGEF and PH domain containing 3. (726 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | Rtn4 | Reticulon. (350 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | FGD1 | FYVE, RhoGEF and PH domain containing 1. (952 aa) |
| | ARHGEF9 | Cdc42 guanine nucleotide exchange factor 9. (518 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (807 aa) |
| | SPATA2 | Spermatogenesis associated 2. (513 aa) |
| | SQSTM1 | Sequestosome 1. (415 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (600 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (986 aa) |
| | TRIO | Trio Rho guanine nucleotide exchange factor. (3062 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (211 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (664 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa) |
| | Arhgef19 | Uncharacterized protein. (157 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (139 aa) |
| | H0WDT2_CAVPO | Ubiquitin-like domain-containing protein. (127 aa) |
| | ARHGEF10 | Rho guanine nucleotide exchange factor 10. (926 aa) |
| | Arhgef25 | Uncharacterized protein. (574 aa) |
| | NGF | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. (308 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (507 aa) |
| | MIB2 | Mindbomb E3 ubiquitin protein ligase 2. (887 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa) |
| | H0WAD6_CAVPO | Ubiquitin-like domain-containing protein. (111 aa) |
| | RTN4R | Reticulon 4 receptor. (434 aa) |
| | LOC100722191 | DUF4203 domain-containing protein. (350 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (272 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (294 aa) |
| | H0W5H3_CAVPO | DH domain-containing protein. (206 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | ARHGEF33 | Rho guanine nucleotide exchange factor 33. (845 aa) |
| | SPPL2B | Signal peptide peptidase like 2B. (582 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (496 aa) |
| | MCF2L | MCF.2 cell line derived transforming sequence like. (1164 aa) |
| | Rnf31 | Uncharacterized protein. (1072 aa) |
| | ARHGEF16 | Rho guanine nucleotide exchange factor 16. (699 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa) |
| | H0VYJ9_CAVPO | Uncharacterized protein. (1418 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (474 aa) |
| | Sestd1 | CRAL-TRIO domain-containing protein. (696 aa) |
