STRINGSTRING
TRAF1 TRAF1 WDR31 WDR31 RBCK1 RBCK1 TNFRSF1A TNFRSF1A USP2 USP2 ULK1 ULK1 UBE2D3 UBE2D3 TRAF2 TRAF2 MAP3K7 MAP3K7 SPATA2 SPATA2 BIRC3 BIRC3 RIPK1 RIPK1 MAP3K20 MAP3K20 Ube2l3 Ube2l3 ENSCPOP00000031632 ENSCPOP00000031632 SMPD3 SMPD3 Ubc Ubc UBE2D1 UBE2D1 H0WDT2_CAVPO H0WDT2_CAVPO TAB1 TAB1 MIB2 MIB2 CHUK CHUK IKBKG IKBKG H0WAD6_CAVPO H0WAD6_CAVPO LOC100722191 LOC100722191 BIRC7 BIRC7 ENSCPOP00000032781 ENSCPOP00000032781 UBE2D2 UBE2D2 STUB1 STUB1 SPPL2B SPPL2B XIAP XIAP Rnf31 Rnf31 MAPKAPK2 MAPKAPK2 CASP10 CASP10 USP21 USP21 TAB2 TAB2 NFATC4 NFATC4 SPPL2A SPPL2A NSMAF NSMAF UBB UBB ENSCPOP00000030204 ENSCPOP00000030204 CASP8 CASP8 SPPL2C SPPL2C MADD MADD SHARPIN SHARPIN BAG4 BAG4 OTULIN OTULIN CLIP3 CLIP3 ADAM17 ADAM17 FADD FADD TBK1 TBK1 TRADD TRADD TNFAIP3 TNFAIP3 IKBKB IKBKB BIRC2 BIRC2 USP4 USP4 CYLD CYLD ULK2 ULK2 IKBKE IKBKE RACK1 RACK1 OTULINL OTULINL CLIP4 CLIP4 OPTN OPTN LOC100731744 LOC100731744 Rps27a Rps27a TAB3 TAB3 SMPD2 SMPD2 TNF TNF OTUD7B OTUD7B TAX1BP1 TAX1BP1 UBA52 UBA52 CFLAR CFLAR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF1TNF receptor-associated factor. (416 aa)
WDR31WD repeat domain 31. (366 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (513 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (611 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1037 aa)
UBE2D3Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
SPATA2Spermatogenesis associated 2. (513 aa)
BIRC3Baculoviral IAP repeat containing 3. (600 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (664 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (711 aa)
Ube2l3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
UbcUncharacterized protein. (159 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (139 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (507 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (887 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
LOC100722191DUF4203 domain-containing protein. (350 aa)
BIRC7Baculoviral IAP repeat containing 7. (272 aa)
ENSCPOP00000032781UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
SPPL2BSignal peptide peptidase like 2B. (582 aa)
XIAPX-linked inhibitor of apoptosis. (496 aa)
Rnf31Uncharacterized protein. (1072 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (474 aa)
USP21Ubiquitin specific peptidase 21; Belongs to the peptidase C19 family. (570 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (665 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
SPPL2ASignal peptide peptidase like 2A. (546 aa)
NSMAFNeutral sphingomyelinase activation associated factor. (900 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
ENSCPOP00000030204Uncharacterized protein. (150 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (481 aa)
SPPL2CSignal peptide peptidase like 2C. (669 aa)
MADDMAP kinase activating death domain. (1627 aa)
SHARPINSHANK associated RH domain interactor. (383 aa)
BAG4BCL2 associated athanogene 4. (456 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (349 aa)
CLIP3CAP-Gly domain containing linker protein 3. (547 aa)
ADAM17ADAM metallopeptidase domain 17. (826 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (206 aa)
TBK1TANK binding kinase 1. (729 aa)
TRADDTNFRSF1A associated via death domain. (310 aa)
TNFAIP3TNF alpha induced protein 3. (789 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (965 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1033 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
OTULINLOTU deubiquitinase with linear linkage specificity like. (284 aa)
CLIP4CAP-Gly domain containing linker protein family member 4. (703 aa)
OPTNOptineurin. (576 aa)
LOC100731744NACHT domain-containing protein. (1402 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (430 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
OTUD7BOTU deubiquitinase 7B. (842 aa)
TAX1BP1Tax1 binding protein 1. (806 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (442 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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