STRINGSTRING
NXPE4 NXPE4 PRKACB PRKACB GDNF GDNF DOK4 DOK4 GFRA4 GFRA4 PDLIM5 PDLIM5 LOC100734206 LOC100734206 GFRA1 GFRA1 GRB2 GRB2 Prkaca Prkaca H0W027_CAVPO H0W027_CAVPO GAB1 GAB1 GAB2 GAB2 DOK5 DOK5 PIK3CD PIK3CD PTPN11 PTPN11 RET RET PLCG1 PLCG1 SHANK3 SHANK3 GFRA2 GFRA2 SHC3 SHC3 GRB7 GRB7 SHC1 SHC1 MAPK7 MAPK7 NRTN NRTN ARTN ARTN DOK1 DOK1 RAP1GAP RAP1GAP PSPN PSPN NXPE2 NXPE2 FNDC3B FNDC3B GRB10 GRB10 PIK3R1 PIK3R1 GFRA3 GFRA3 PIK3CA PIK3CA FNDC3A FNDC3A DOK6 DOK6 FRS2 FRS2 SOS1 SOS1 PDLIM7 PDLIM7 DOK2 DOK2 PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NXPE4Neurexophilin and PC-esterase domain family member 4. (544 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GDNFGlial cell derived neurotrophic factor. (210 aa)
DOK4Docking protein 4. (326 aa)
GFRA4GDNF family receptor alpha 4. (280 aa)
PDLIM5PDZ and LIM domain 5. (614 aa)
LOC100734206Uncharacterized protein. (461 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (468 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
GAB2GRB2 associated binding protein 2. (635 aa)
DOK5Docking protein 5. (306 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (588 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1694 aa)
GFRA2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (454 aa)
SHC3SHC adaptor protein 3. (418 aa)
GRB7Growth factor receptor bound protein 7. (531 aa)
SHC1SHC adaptor protein 1. (583 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (797 aa)
NRTNNeurturin. (197 aa)
ARTNArtemin. (223 aa)
DOK1Docking protein 1. (483 aa)
RAP1GAPRAP1 GTPase activating protein. (744 aa)
PSPNPersephin. (159 aa)
NXPE2Neurexophilin and PC-esterase domain family member 2. (558 aa)
FNDC3BFibronectin type III domain containing 3B. (1101 aa)
GRB10Growth factor receptor bound protein 10. (616 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GFRA3GDNF family receptor alpha 3. (407 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
FNDC3AFibronectin type III domain containing 3A. (1172 aa)
DOK6Docking protein 6. (331 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
PDLIM7PDZ and LIM domain 7. (456 aa)
DOK2Docking protein 2. (412 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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