STRINGSTRING
SMURF1 SMURF1 UBA52 UBA52 PSMB8 PSMB8 PSMB1 PSMB1 TGFB1 TGFB1 PSMB6 PSMB6 H0UWM4_CAVPO H0UWM4_CAVPO PSMB9 PSMB9 PSMD13 PSMD13 FNDC3A FNDC3A PSMC4 PSMC4 EP300 EP300 TEAD3 TEAD3 Rps27a Rps27a PSMD6 PSMD6 SMAD4 SMAD4 PSMB7 PSMB7 MAML2 MAML2 PSMC6 PSMC6 PSMD11 PSMD11 H0VHS7_CAVPO H0VHS7_CAVPO PSMD8 PSMD8 PSMD7 PSMD7 PSMC5 PSMC5 FNDC3B FNDC3B ZFHX4 ZFHX4 NOTCH1 NOTCH1 HDAC4 HDAC4 PSMA5 PSMA5 PSMF1 PSMF1 PSMB5 PSMB5 PSMA7 PSMA7 TCF7L1 TCF7L1 Psmd10 Psmd10 PSMD3 PSMD3 PSMB4 PSMB4 PSMA1 PSMA1 PSMC2 PSMC2 H0VWS1_CAVPO H0VWS1_CAVPO ZFHX2 ZFHX2 Psmd9 Psmd9 PSMA4 PSMA4 NINJ2 NINJ2 PSMB3 PSMB3 PSMD5 PSMD5 H0WAD6_CAVPO H0WAD6_CAVPO RBPJL RBPJL TEAD4 TEAD4 PSMB10 PSMB10 TCF7 TCF7 H0WDT2_CAVPO H0WDT2_CAVPO RUNX1 RUNX1 MDM2 MDM2 PSMD1 PSMD1 HES1 HES1 TCF7L2 TCF7L2 PSMA3 PSMA3 BRD2 BRD2 ENSCPOP00000023065 ENSCPOP00000023065 PSME1 PSME1 LEF1 LEF1 PSMC3 PSMC3 ENSCPOP00000024615 ENSCPOP00000024615 SMURF2 SMURF2 PSMD2 PSMD2 CDKN1A CDKN1A TEAD1 TEAD1 CCND1 CCND1 PSMD14 PSMD14 PSMD4 PSMD4 TEAD2 TEAD2 PSMD12 PSMD12 PSMB2 PSMB2 PSMA6 PSMA6 TP53 TP53 UBB UBB RUNX3 RUNX3 SMAD3 SMAD3 PSMC1 PSMC1 ENSCPOP00000031632 ENSCPOP00000031632 ZFHX3 ZFHX3 PSME2 PSME2 Ubc Ubc Psma2 Psma2 PSME3 PSME3 MAMLD1 MAMLD1 CTNNB1 CTNNB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMURF1E3 ubiquitin-protein ligase. (757 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
PSMB8Proteasome subunit beta. (273 aa)
PSMB1Proteasome subunit beta. (241 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
PSMB6Proteasome subunit beta. (239 aa)
H0UWM4_CAVPOUncharacterized protein. (473 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
FNDC3AFibronectin type III domain containing 3A. (1172 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
EP300E1A binding protein p300. (2425 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (456 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PSMB7Proteasome subunit beta. (277 aa)
MAML2Mastermind like transcriptional coactivator 2. (958 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
H0VHS7_CAVPOUncharacterized protein. (85 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
FNDC3BFibronectin type III domain containing 3B. (1101 aa)
ZFHX4Zinc finger homeobox 4. (3080 aa)
NOTCH1Notch receptor 1. (2472 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1078 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
ZFHX2Zinc finger homeobox 2. (2554 aa)
Psmd9PDZ domain-containing protein. (223 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
NINJ2Ninjurin 2. (132 aa)
PSMB3Proteasome subunit beta. (207 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (450 aa)
PSMB10Proteasome subunit beta. (273 aa)
TCF7Transcription factor 7. (262 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (465 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
TCF7L2Transcription factor 7 like 2. (350 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
BRD2Bromodomain containing 2. (804 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
PSME1Proteasome activator subunit 1. (249 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
ENSCPOP00000024615Bromo domain-containing protein. (84 aa)
SMURF2E3 ubiquitin-protein ligase. (782 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (169 aa)
TEAD1TEA domain transcription factor 1. (445 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
TEAD2TEA domain transcription factor 2. (452 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (430 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
ZFHX3Zinc finger homeobox 3. (3669 aa)
PSME2Proteasome activator subunit 2. (239 aa)
UbcUncharacterized protein. (159 aa)
Psma2Proteasome subunit alpha type. (234 aa)
PSME3Proteasome activator subunit 3. (254 aa)
MAMLD1Mastermind like domain containing 1. (714 aa)
CTNNB1Catenin beta 1. (781 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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