STRINGSTRING
ENSCPOP00000026400 ENSCPOP00000026400 ENSCPOP00000026646 ENSCPOP00000026646 Cav2 Cav2 ZDHHC21 ZDHHC21 CAV1 CAV1 POLR2H POLR2H C11orf88 C11orf88 ENSCPOP00000028672 ENSCPOP00000028672 CCNT1 CCNT1 ENSCPOP00000029061 ENSCPOP00000029061 ENSCPOP00000029297 ENSCPOP00000029297 PTGES3 PTGES3 GTF2A2 GTF2A2 POLR2F POLR2F EREG EREG GNAI1 GNAI1 GTF2F2 GTF2F2 ENSCPOP00000030090 ENSCPOP00000030090 LOC100734206 LOC100734206 KDM1A KDM1A POLR2K POLR2K ENSCPOP00000030509 ENSCPOP00000030509 LOC106027456 LOC106027456 AKT2 AKT2 TBP TBP CSDE1 CSDE1 POLR2G POLR2G HIST3H3 HIST3H3 GTF2A1L GTF2A1L KANK4 KANK4 HSPB1 HSPB1 CDKN1B CDKN1B HRAS HRAS LOC100731150 LOC100731150 LOC100728920 LOC100728920 ZNF217 ZNF217 H0W027_CAVPO H0W027_CAVPO KANK2 KANK2 GNAT3 GNAT3 JUND JUND FOSB FOSB STRN3 STRN3 AKT3 AKT3 POLR2A POLR2A ZC3H12D ZC3H12D MYB MYB MOV10 MOV10 EPGN EPGN MAPK1 MAPK1 H2BC1 H2BC1 GTF2F1 GTF2F1 SPHK1 SPHK1 STRN STRN USF2 USF2 POLR2I POLR2I TBPL1 TBPL1 GNAI3 GNAI3 ERBB4 ERBB4 ZC3H12A ZC3H12A H0VHS7_CAVPO H0VHS7_CAVPO KRAS KRAS NRAS NRAS Cdk9 Cdk9 HBEGF HBEGF TGFA TGFA EGFR EGFR ELK1 ELK1 H0VDT0_CAVPO H0VDT0_CAVPO GATA3 GATA3 ESR1 ESR1 TRPS1 TRPS1 NCOA3 NCOA3 PIK3R1 PIK3R1 MMP9 MMP9 ZDHHC7 ZDHHC7 DDX5 DDX5 PTGES3L PTGES3L GREB1 GREB1 PIK3CA PIK3CA PRMT8 PRMT8 EP300 EP300 IGF1R IGF1R UHMK1 UHMK1 POLR2C POLR2C NOS3 NOS3 USF1 USF1 HSP90AB1 HSP90AB1 Cited1 Cited1 PDPK1 PDPK1 GTF2A1 GTF2A1 CHD1 CHD1 POLR2D POLR2D FKBP4 FKBP4 Hsp90aa1 Hsp90aa1 POLR2E POLR2E Polr2j Polr2j STRN4 STRN4 PPID PPID PTK2 PTK2 EGF EGF LOC100732911 LOC100732911 ESR2 ESR2 Foxo3 Foxo3 LOC100730459 LOC100730459 GREB1L GREB1L SP1 SP1 SHC1 SHC1 TLE3 TLE3 LOC111756490 LOC111756490 LOC100735042 LOC100735042 MMP2 MMP2 BTC BTC S1PR3 S1PR3 H3F3B H3F3B CREB1 CREB1 PRMT1 PRMT1 WDR64 WDR64 LOC100735546 LOC100735546 FKBP5 FKBP5 LOC100735825 LOC100735825 ZC3H12C ZC3H12C KAT5 KAT5 XPO1 XPO1 LOC100725824 LOC100725824 ENSCPOP00000022942 ENSCPOP00000022942 MMP3 MMP3 PPP5C PPP5C LOC100717510 LOC100717510 KANK1 KANK1 CARM1 CARM1 NCOA1 NCOA1 ENSCPOP00000023894 ENSCPOP00000023894 Pgr Pgr H3-3A H3-3A MAPK3 MAPK3 ENSCPOP00000024231 ENSCPOP00000024231 ENSCPOP00000024251 ENSCPOP00000024251 LOC100733876 LOC100733876 ENSCPOP00000024311 ENSCPOP00000024311 ENSCPOP00000024347 ENSCPOP00000024347 HIST2H2BE HIST2H2BE ENSCPOP00000024383 ENSCPOP00000024383 ENSCPOP00000024615 ENSCPOP00000024615 CXXC5 CXXC5 H2BC18 H2BC18 GNG2 GNG2 LOC100728325 LOC100728325 POLR2L POLR2L POLR2B POLR2B EBAG9 EBAG9 GNAI2 GNAI2 NRIP1 NRIP1 AREG AREG LOC100713990 LOC100713990 AKT1 AKT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCPOP00000026400annotation not available (125 aa)
ENSCPOP00000026646annotation not available (126 aa)
Cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (125 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
C11orf88Chromosome 11 open reading frame 88. (168 aa)
ENSCPOP00000028672annotation not available (136 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (727 aa)
ENSCPOP00000029061annotation not available (126 aa)
ENSCPOP00000029297annotation not available (103 aa)
PTGES3Prostaglandin E synthase 3. (160 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
EREGEpiregulin. (164 aa)
GNAI1Uncharacterized protein. (330 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
ENSCPOP00000030090annotation not available (126 aa)
LOC100734206Uncharacterized protein. (461 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (865 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
ENSCPOP00000030509Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC106027456annotation not available (126 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TBPTATA-box binding protein. (321 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
HIST3H3Histone cluster 3 H3. (128 aa)
GTF2A1LGeneral transcription factor IIA subunit 1 like. (468 aa)
KANK4KN motif and ankyrin repeat domains 4. (859 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC100731150annotation not available (103 aa)
LOC100728920Histone domain-containing protein; Belongs to the histone H2B family. (128 aa)
ZNF217Zinc finger protein 217. (914 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
KANK2KN motif and ankyrin repeat domains 2. (841 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (320 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (340 aa)
STRN3Striatin 3. (786 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1833 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (464 aa)
MYBMYB proto-oncogene, transcription factor. (743 aa)
MOV10Mov10 RISC complex RNA helicase. (1063 aa)
EPGNEpithelial mitogen. (133 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (522 aa)
SPHK1Sphingosine kinase 1. (386 aa)
STRNStriatin. (780 aa)
USF2Upstream transcription factor 2, c-fos interacting. (360 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
TBPL1TATA-box binding protein like 1. (179 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
ERBB4Receptor protein-tyrosine kinase. (1263 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (550 aa)
H0VHS7_CAVPOUncharacterized protein. (85 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
Cdk9Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
TGFATransforming growth factor alpha. (159 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
ELK1ETS transcription factor ELK1. (422 aa)
H0VDT0_CAVPOProtein kinase domain-containing protein. (337 aa)
GATA3GATA binding protein 3. (443 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
TRPS1Transcriptional repressor GATA binding 1. (1285 aa)
NCOA3Nuclear receptor coactivator. (1418 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MMP9Matrix metallopeptidase 9. (715 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
PTGES3LProstaglandin E synthase 3 like. (149 aa)
GREB1Uncharacterized protein. (1882 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (376 aa)
EP300E1A binding protein p300. (2425 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa)
USF1Upstream transcription factor 1. (310 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
Cited1Uncharacterized protein. (61 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (550 aa)
GTF2A1General transcription factor IIA subunit 1. (377 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1666 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
FKBP4Peptidylprolyl isomerase. (458 aa)
Hsp90aa1Heat shock protein 90 alpha family class A member 1. (733 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
Polr2jRNA polymerase II subunit J. (117 aa)
STRN4Striatin 4. (777 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
LOC100732911P-type domain-containing protein. (56 aa)
ESR2Estrogen receptor 2. (568 aa)
Foxo3Forkhead box O3. (660 aa)
LOC100730459Uncharacterized protein. (280 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1884 aa)
SP1Sp1 transcription factor. (786 aa)
SHC1SHC adaptor protein 1. (583 aa)
TLE3TLE family member 3, transcriptional corepressor. (769 aa)
LOC111756490Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC100735042Histone domain-containing protein; Belongs to the histone H2B family. (125 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
BTCBetacellulin. (183 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (373 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
WDR64WD repeat domain 64. (1056 aa)
LOC100735546Histone H2B; Belongs to the histone H2B family. (126 aa)
FKBP5Peptidylprolyl isomerase. (456 aa)
LOC100735825Histone H3; Belongs to the histone H3 family. (136 aa)
ZC3H12CZinc finger CCCH-type containing 12C. (886 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
XPO1Exportin 1. (1062 aa)
LOC100725824HATPase_c domain-containing protein. (695 aa)
ENSCPOP00000022942Uncharacterized protein. (168 aa)
MMP3Matrix metallopeptidase 3. (479 aa)
PPP5CSerine/threonine-protein phosphatase. (533 aa)
LOC100717510Histone H2B; Belongs to the histone H2B family. (126 aa)
KANK1KN motif and ankyrin repeat domains 1. (1353 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (641 aa)
NCOA1Nuclear receptor coactivator. (1442 aa)
ENSCPOP00000023894annotation not available (126 aa)
PgrUncharacterized protein. (428 aa)
H3-3AH3.3 histone A. (136 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ENSCPOP00000024231annotation not available (136 aa)
ENSCPOP00000024251ANK_REP_REGION domain-containing protein. (179 aa)
LOC100733876annotation not available (103 aa)
ENSCPOP00000024311annotation not available (126 aa)
ENSCPOP00000024347annotation not available (103 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
ENSCPOP00000024383annotation not available (126 aa)
ENSCPOP00000024615Bromo domain-containing protein. (84 aa)
CXXC5CXXC finger protein 5. (317 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
LOC100728325annotation not available (103 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
NRIP1Nuclear receptor interacting protein 1. (1157 aa)
AREGAmphiregulin. (241 aa)
LOC100713990Histone H2B; Belongs to the histone H2B family. (126 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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