STRINGSTRING
GUF1 GUF1 Psmd10 Psmd10 OTUD3 OTUD3 PSMD3 PSMD3 PSMB4 PSMB4 PSMA1 PSMA1 AKT3 AKT3 Ubc Ubc Psma2 Psma2 PSME3 PSME3 RNF141 RNF141 H0VWS1_CAVPO H0VWS1_CAVPO XIAP XIAP Psmd9 Psmd9 STUB1 STUB1 PSMA4 PSMA4 PTEN PTEN AKT1 AKT1 WWP2 WWP2 Ly6g5b Ly6g5b PSMB3 PSMB3 PSMB11 PSMB11 PSMC2 PSMC2 PSMD5 PSMD5 H0WAD6_CAVPO H0WAD6_CAVPO PSMB10 PSMB10 H0WDT2_CAVPO H0WDT2_CAVPO PSMD1 PSMD1 PSMA3 PSMA3 ENSCPOP00000023065 ENSCPOP00000023065 PSME1 PSME1 TRIM7 TRIM7 PSMC3 PSMC3 PSMD2 PSMD2 PSMD14 PSMD14 PSMD4 PSMD4 TNKS TNKS PSMD12 PSMD12 PSMB2 PSMB2 PSMA6 PSMA6 UBB UBB PSMC1 PSMC1 AKT2 AKT2 ENSCPOP00000031632 ENSCPOP00000031632 PSME2 PSME2 UBA52 UBA52 NEDD4 NEDD4 PSMB8 PSMB8 MKRN1 MKRN1 PSMB1 PSMB1 MKRN2 MKRN2 PSMB6 PSMB6 PSMB9 PSMB9 TNKS2 TNKS2 USP13 USP13 PSMD13 PSMD13 PSMC4 PSMC4 RNF146 RNF146 Csnk2a1 Csnk2a1 Rps27a Rps27a PSMD6 PSMD6 FRK FRK OTUD4 OTUD4 PSMB7 PSMB7 CSNK2A2 CSNK2A2 PSMC6 PSMC6 PSMD11 PSMD11 CSNK2B CSNK2B PSMD8 PSMD8 PSMD7 PSMD7 PSMC5 PSMC5 PSME4 PSME4 PSMA8 PSMA8 TRIM27 TRIM27 PSMA5 PSMA5 PSMF1 PSMF1 PSMB5 PSMB5 PSMA7 PSMA7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GUF1Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (633 aa)
Psmd10ANK_REP_REGION domain-containing protein. (232 aa)
OTUD3OTU deubiquitinase 3. (397 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSMA1Proteasome subunit alpha type. (270 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
UbcUncharacterized protein. (159 aa)
Psma2Proteasome subunit alpha type. (234 aa)
PSME3Proteasome activator subunit 3. (254 aa)
RNF141Ring finger protein 141. (230 aa)
H0VWS1_CAVPOANK_REP_REGION domain-containing protein. (213 aa)
XIAPX-linked inhibitor of apoptosis. (496 aa)
Psmd9PDZ domain-containing protein. (223 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
Ly6g5bUncharacterized protein. (195 aa)
PSMB3Proteasome subunit beta. (207 aa)
PSMB11Proteasome subunit beta. (297 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (458 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
PSMB10Proteasome subunit beta. (273 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
ENSCPOP00000023065ANK_REP_REGION domain-containing protein. (179 aa)
PSME1Proteasome activator subunit 1. (249 aa)
TRIM7Tripartite motif containing 7. (303 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
PSME2Proteasome activator subunit 2. (239 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
PSMB8Proteasome subunit beta. (273 aa)
MKRN1Makorin ring finger protein 1. (463 aa)
PSMB1Proteasome subunit beta. (241 aa)
MKRN2Makorin ring finger protein 2. (408 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMB9Proteasome subunit beta. (219 aa)
TNKS2Poly [ADP-ribose] polymerase. (1162 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (823 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (315 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
RNF146Ring finger protein 146. (356 aa)
Csnk2a1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
FRKTyrosine-protein kinase. (510 aa)
OTUD4OTU deubiquitinase 4. (1076 aa)
PSMB7Proteasome subunit beta. (277 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (349 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (244 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSME4Proteasome activator subunit 4. (1827 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
TRIM27Tripartite motif containing 27. (504 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMA7Proteasome endopeptidase complex. (248 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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