STRINGSTRING
AMHR2 AMHR2 CGN CGN IRX1 IRX1 IRX4 IRX4 NCOR2 NCOR2 F11R F11R STUB1 STUB1 ITGB6 ITGB6 SP1 SP1 BMPR1A BMPR1A AMH AMH H0W9U2_CAVPO H0W9U2_CAVPO H0WAD6_CAVPO H0WAD6_CAVPO MEIS3 MEIS3 DRAP1 DRAP1 BMP10 BMP10 H0WDT2_CAVPO H0WDT2_CAVPO UBE2D1 UBE2D1 TFDP2 TFDP2 NOG NOG Inhba Inhba BMPR1B BMPR1B CCNK CCNK MAPK3 MAPK3 ENSCPOP00000024428 ENSCPOP00000024428 MKX MKX NEDD4L NEDD4L SMURF2 SMURF2 SMAD7 SMAD7 PMEPA1 PMEPA1 Fkbp1a Fkbp1a LTBP4 LTBP4 IRX5 IRX5 CER1 CER1 CCNC CCNC ZCCHC4 ZCCHC4 Itgb3 Itgb3 NEDD8 NEDD8 E2F4 E2F4 PARD6A PARD6A SNW1 SNW1 Cdk9 Cdk9 Smad9 Smad9 TRIM33 TRIM33 FOXH1 FOXH1 ITGA8 ITGA8 ITGB5 ITGB5 CCNQ CCNQ ITGB8 ITGB8 H0VDT0_CAVPO H0VDT0_CAVPO ATP1B4 ATP1B4 FURIN FURIN Tgif1 Tgif1 TGFBR2 TGFBR2 ACVR2B ACVR2B TGFB3 TGFB3 RNF111 RNF111 CHRDL1 CHRDL1 CCNT1 CCNT1 GREM2 GREM2 BMPR2 BMPR2 CBL CBL TGIF2 TGIF2 UBE2M UBE2M UBB UBB CCNT2 CCNT2 ENSCPOP00000030285 ENSCPOP00000030285 FSTL1 FSTL1 BMP2 BMP2 IRX3 IRX3 CDK8 CDK8 FBN1 FBN1 USP9X USP9X SMAD3 SMAD3 RHOA RHOA ZFYVE9 ZFYVE9 LTBP3 LTBP3 ENSCPOP00000031632 ENSCPOP00000031632 ITGB1 ITGB1 Ubc Ubc INHBB INHBB Irx2 Irx2 BAMBI BAMBI SMAD1 SMAD1 PCSK4 PCSK4 ACVR1 ACVR1 ACVR2A ACVR2A Zfyve16 Zfyve16 HDAC1 HDAC1 TGFB2 TGFB2 FSTL3 FSTL3 ACVR1C ACVR1C CHRDL2 CHRDL2 LTBP1 LTBP1 SKIL SKIL SMAD4 SMAD4 SKI SKI Rps27a Rps27a SMAD5 SMAD5 PARD3B PARD3B MTMR4 MTMR4 PPM1A PPM1A ACVRL1 ACVRL1 SMAD6 SMAD6 MEN1 MEN1 RBL1 RBL1 TGFB1 TGFB1 STRAP STRAP LTBP2 LTBP2 ACVR1B ACVR1B FST FST NCOR1 NCOR1 UBA52 UBA52 SMURF1 SMURF1 GDF2 GDF2 MAPK1 MAPK1 SMAD2 SMAD2 TFDP1 TFDP1 IRX6 IRX6 TGFBR1 TGFBR1 ITGAV ITGAV Parp1 Parp1 PARD3 PARD3 JUNB JUNB
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (565 aa)
CGNCingulin. (1200 aa)
IRX1Iroquois homeobox 1. (390 aa)
IRX4Iroquois homeobox 4. (425 aa)
NCOR2Nuclear receptor corepressor 2. (2467 aa)
F11RF11 receptor. (299 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (788 aa)
SP1Sp1 transcription factor. (786 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
AMHAnti-Mullerian hormone. (560 aa)
H0W9U2_CAVPOUncharacterized protein. (143 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
MEIS3Meis homeobox 3. (375 aa)
DRAP1DR1 associated protein 1. (212 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (139 aa)
TFDP2Transcription factor. (446 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (210 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
CCNKCyclin K; Belongs to the cyclin family. (582 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
MKXMohawk homeobox. (352 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (992 aa)
SMURF2E3 ubiquitin-protein ligase. (782 aa)
SMAD7SMAD family member 7. (221 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (245 aa)
Fkbp1aPeptidylprolyl isomerase. (108 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1585 aa)
IRX5Iroquois homeobox 5. (477 aa)
CER1Cerberus 1, DAN family BMP antagonist. (270 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
ZCCHC4Zinc finger CCHC-type containing 4. (518 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (735 aa)
NEDD8NEDD8 ubiquitin like modifier. (83 aa)
E2F4E2F transcription factor 4. (411 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
SNW1SNW domain containing 1. (535 aa)
Cdk9Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
Smad9Mothers against decapentaplegic homolog. (457 aa)
TRIM33Tripartite motif containing 33. (1128 aa)
FOXH1Forkhead box H1. (370 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CCNQCyclin Q; Belongs to the cyclin family. (249 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
H0VDT0_CAVPOProtein kinase domain-containing protein. (337 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (796 aa)
Tgif1Homeobox domain-containing protein. (99 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RNF111Ring finger protein 111. (994 aa)
CHRDL1Chordin like 1. (459 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (727 aa)
GREM2Gremlin. (168 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
CBLCbl proto-oncogene. (894 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (734 aa)
ENSCPOP00000030285Uncharacterized protein. (1035 aa)
FSTL1Follistatin like 1. (287 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
IRX3Iroquois homeobox 3. (484 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (449 aa)
FBN1Fibrillin 1. (2872 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2558 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RHOARas homolog family member A. (193 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1322 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1017 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
UbcUncharacterized protein. (159 aa)
INHBBInhibin subunit beta B. (374 aa)
Irx2Iroquois homeobox 2. (471 aa)
BAMBIBMP and activin membrane bound inhibitor. (234 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (639 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (489 aa)
Zfyve16FYVE-type domain-containing protein. (1562 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
FSTL3Follistatin like 3. (258 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (479 aa)
CHRDL2Chordin like 2. (452 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1577 aa)
SKILSKI like proto-oncogene. (679 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SKISKI proto-oncogene. (586 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PARD3BPar-3 family cell polarity regulator beta. (1026 aa)
MTMR4Myotubularin related protein 4. (1189 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SMAD6Mothers against decapentaplegic homolog. (508 aa)
MEN1Menin 1. (615 aa)
RBL1RB transcriptional corepressor like 1. (1051 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1773 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (500 aa)
FSTFollistatin. (344 aa)
NCOR1Nuclear receptor corepressor 1. (2389 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
GDF2Growth differentiation factor 2. (411 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TFDP1Transcription factor. (411 aa)
IRX6Iroquois homeobox 6. (445 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (963 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
PARD3Par-3 family cell polarity regulator. (1294 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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