STRINGSTRING
MAML2 MAML2 JAG1 JAG1 Ubc Ubc ENSCPOP00000031632 ENSCPOP00000031632 UBB UBB PSENEN PSENEN PBX3 PBX3 TACC3 TACC3 WWP2 WWP2 HEY1 HEY1 HEYL HEYL DLGAP5 DLGAP5 NEURL1B NEURL1B PSEN1 PSEN1 HES5 HES5 IKZF1 IKZF1 HES1 HES1 H0WDT2_CAVPO H0WDT2_CAVPO HEY2 HEY2 H0WAD6_CAVPO H0WAD6_CAVPO PBX2 PBX2 DLL1 DLL1 NOTCH3 NOTCH3 NCSTN NCSTN H0VKD6_CAVPO H0VKD6_CAVPO DLL4 DLL4 YBX1 YBX1 ADAM10 ADAM10 JAG2 JAG2 NEURL1 NEURL1 APH1A APH1A PBX1 PBX1 Rps27a Rps27a MIB1 MIB1 APH1B APH1B PSEN2 PSEN2 EGF EGF UBA52 UBA52 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAML2Mastermind like transcriptional coactivator 2. (958 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
UbcUncharacterized protein. (159 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
PBX3PBX homeobox 3. (434 aa)
TACC3TACC_C domain-containing protein. (783 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
DLGAP5DLG associated protein 5. (815 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (315 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
HES5Hes family bHLH transcription factor 5. (164 aa)
IKZF1IKAROS family zinc finger 1. (511 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (333 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
PBX2PBX homeobox 2. (430 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (607 aa)
NOTCH3Notch receptor 3. (2141 aa)
NCSTNNicastrin. (709 aa)
H0VKD6_CAVPOUncharacterized protein. (184 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
YBX1YB1. (324 aa)
ADAM10ADAM metallopeptidase domain 10. (679 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1095 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
PBX1PBX homeobox 1. (430 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (963 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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