18 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
	ENSCPOP00000032088	Uncharacterized protein. (191 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (967 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
	NFKBIB	NFKB inhibitor beta. (355 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (549 aa)
	H0WAS6_CAVPO	Uncharacterized protein. (214 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
	APP	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
	LOC100718750	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (133 aa)
	Hmgb1	annotation not available (215 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (192 aa)
	S100B	Protein S100; Belongs to the S-100 family. (92 aa)
	NKIRAS2	NFKB inhibitor interacting Ras like 2. (191 aa)
	AGER	Advanced glycosylation end-product specific receptor. (377 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (854 aa)
	RNF135	Ring finger protein 135. (368 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSCPOP00000000519	ENSCPOP00000020780	Advanced glycosylation end-product specific receptor.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.711
AGER	ENSCPOP00000032088	ENSCPOP00000000519	ENSCPOP00000032088	Advanced glycosylation end-product specific receptor.	Uncharacterized protein.	0.767
AGER	H0WAS6_CAVPO	ENSCPOP00000000519	ENSCPOP00000020089	Advanced glycosylation end-product specific receptor.	Uncharacterized protein.	0.767
AGER	Hmgb1	ENSCPOP00000000519	ENSCPOP00000023849	Advanced glycosylation end-product specific receptor.	annotation not available	0.767
AGER	NFKB1	ENSCPOP00000000519	ENSCPOP00000007014	Advanced glycosylation end-product specific receptor.	Nuclear factor kappa B subunit 1.	0.570
AGER	NFKB2	ENSCPOP00000000519	ENSCPOP00000004362	Advanced glycosylation end-product specific receptor.	Nuclear factor kappa B subunit 2.	0.547
AGER	RELA	ENSCPOP00000000519	ENSCPOP00000016204	Advanced glycosylation end-product specific receptor.	RELA proto-oncogene, NF-kB subunit.	0.550
AGER	S100B	ENSCPOP00000000519	ENSCPOP00000026644	Advanced glycosylation end-product specific receptor.	Protein S100; Belongs to the S-100 family.	0.993
APP	AGER	ENSCPOP00000020780	ENSCPOP00000000519	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Advanced glycosylation end-product specific receptor.	0.711
APP	NFKB1	ENSCPOP00000020780	ENSCPOP00000007014	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Nuclear factor kappa B subunit 1.	0.699
APP	NFKB2	ENSCPOP00000020780	ENSCPOP00000004362	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Nuclear factor kappa B subunit 2.	0.622
APP	NFKBIA	ENSCPOP00000020780	ENSCPOP00000004911	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	NFKB inhibitor alpha.	0.401
APP	RELA	ENSCPOP00000020780	ENSCPOP00000016204	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	RELA proto-oncogene, NF-kB subunit.	0.523
APP	S100B	ENSCPOP00000020780	ENSCPOP00000026644	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Protein S100; Belongs to the S-100 family.	0.645
CHUK	IKBKB	ENSCPOP00000032009	ENSCPOP00000009478	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.999
CHUK	IKBKG	ENSCPOP00000032009	ENSCPOP00000020158	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.998
CHUK	NFKB1	ENSCPOP00000032009	ENSCPOP00000007014	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor kappa B subunit 1.	0.975
CHUK	NFKB2	ENSCPOP00000032009	ENSCPOP00000004362	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor kappa B subunit 2.	0.964
CHUK	NFKBIA	ENSCPOP00000032009	ENSCPOP00000004911	Component of inhibitor of nuclear factor kappa B kinase complex.	NFKB inhibitor alpha.	0.999
CHUK	NFKBIB	ENSCPOP00000032009	ENSCPOP00000011870	Component of inhibitor of nuclear factor kappa B kinase complex.	NFKB inhibitor beta.	0.988