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Rps27a Rps27a UBA52 UBA52 SH2B3 SH2B3 SOS1 SOS1 PIK3CA PIK3CA FLT3 FLT3 PIK3R1 PIK3R1 SOCS2 SOCS2 GRB10 GRB10 SYK SYK NRAS NRAS KRAS KRAS SLA2 SLA2 GAB2 GAB2 AKT3 AKT3 Foxo3 Foxo3 H0WAD6_CAVPO H0WAD6_CAVPO FLT3LG FLT3LG H0WDT2_CAVPO H0WDT2_CAVPO SOCS6 SOCS6 CSK CSK PTPRJ PTPRJ AKT1 AKT1 GRAP2 GRAP2 CBL CBL UBB UBB AKT2 AKT2 ENSCPOP00000031632 ENSCPOP00000031632 GRB2 GRB2 CSDE1 CSDE1 Ubc Ubc CDKN1B CDKN1B HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
SH2B3SH2B adaptor protein 3. (557 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (987 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
GRB10Growth factor receptor bound protein 10. (616 aa)
SYKTyrosine-protein kinase. (579 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SLA2Src like adaptor 2. (276 aa)
GAB2GRB2 associated binding protein 2. (635 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
Foxo3Forkhead box O3. (660 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (179 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
CSKTyrosine-protein kinase. (450 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1311 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GRAP2GRB2 related adaptor protein 2. (327 aa)
CBLCbl proto-oncogene. (894 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
UbcUncharacterized protein. (159 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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