node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM10 | ADAM17 | ENSCPOP00000009443 | ENSCPOP00000010172 | ADAM metallopeptidase domain 10. | ADAM metallopeptidase domain 17. | 0.943 |
ADAM10 | APP | ENSCPOP00000009443 | ENSCPOP00000020780 | ADAM metallopeptidase domain 10. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.823 |
ADAM10 | PSEN1 | ENSCPOP00000009443 | ENSCPOP00000024787 | ADAM metallopeptidase domain 10. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.692 |
ADAM10 | PSEN2 | ENSCPOP00000009443 | ENSCPOP00000001654 | ADAM metallopeptidase domain 10. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.636 |
ADAM10 | TGFA | ENSCPOP00000009443 | ENSCPOP00000008757 | ADAM metallopeptidase domain 10. | Transforming growth factor alpha. | 0.477 |
ADAM17 | ADAM10 | ENSCPOP00000010172 | ENSCPOP00000009443 | ADAM metallopeptidase domain 17. | ADAM metallopeptidase domain 10. | 0.943 |
ADAM17 | APP | ENSCPOP00000010172 | ENSCPOP00000020780 | ADAM metallopeptidase domain 17. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.601 |
ADAM17 | PSEN1 | ENSCPOP00000010172 | ENSCPOP00000024787 | ADAM metallopeptidase domain 17. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.551 |
ADAM17 | PSEN2 | ENSCPOP00000010172 | ENSCPOP00000001654 | ADAM metallopeptidase domain 17. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.657 |
ADAM17 | TGFA | ENSCPOP00000010172 | ENSCPOP00000008757 | ADAM metallopeptidase domain 17. | Transforming growth factor alpha. | 0.650 |
APP | ADAM10 | ENSCPOP00000020780 | ENSCPOP00000009443 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | ADAM metallopeptidase domain 10. | 0.823 |
APP | ADAM17 | ENSCPOP00000020780 | ENSCPOP00000010172 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | ADAM metallopeptidase domain 17. | 0.601 |
APP | CD44 | ENSCPOP00000020780 | ENSCPOP00000007016 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | CD44 molecule (Indian blood group). | 0.472 |
APP | PSEN1 | ENSCPOP00000020780 | ENSCPOP00000024787 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.995 |
APP | PSEN2 | ENSCPOP00000020780 | ENSCPOP00000001654 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.966 |
CD44 | APP | ENSCPOP00000007016 | ENSCPOP00000020780 | CD44 molecule (Indian blood group). | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.472 |
CD44 | CDC42 | ENSCPOP00000007016 | ENSCPOP00000031577 | CD44 molecule (Indian blood group). | Cell division cycle 42. | 0.908 |
CD44 | EZR | ENSCPOP00000007016 | ENSCPOP00000032958 | CD44 molecule (Indian blood group). | Ezrin. | 0.859 |
CD44 | MSN | ENSCPOP00000007016 | ENSCPOP00000031240 | CD44 molecule (Indian blood group). | Moesin. | 0.920 |
CD44 | RDX | ENSCPOP00000007016 | ENSCPOP00000022333 | CD44 molecule (Indian blood group). | Radixin. | 0.962 |