STRINGSTRING
NCK2 NCK2 PSEN2 PSEN2 PLEK PLEK HMGCR HMGCR ISL1 ISL1 CD44 CD44 TGFA TGFA ROCK1 ROCK1 ADAM10 ADAM10 ADAM17 ADAM17 APP APP RDX RDX NCK1 NCK1 PSEN1 PSEN1 CDC42 CDC42 EZR EZR RHOA RHOA MSN MSN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCK2Cytoplasmic protein. (377 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
PLEKPleckstrin. (350 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
ISL1ISL LIM homeobox 1. (349 aa)
CD44CD44 molecule (Indian blood group). (660 aa)
TGFATransforming growth factor alpha. (159 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
ADAM10ADAM metallopeptidase domain 10. (679 aa)
ADAM17ADAM metallopeptidase domain 17. (826 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
RDXRadixin. (604 aa)
NCK1Cytoplasmic protein. (377 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CDC42Cell division cycle 42. (191 aa)
EZREzrin. (586 aa)
RHOARas homolog family member A. (193 aa)
MSNMoesin. (577 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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