STRINGSTRING
IL21 IL21 TRPV1 TRPV1 TAC1 TAC1 Trpa1 Trpa1 ANXA9 ANXA9 BDNF BDNF TRPV4 TRPV4 ANXA4 ANXA4 ANXA13 ANXA13 EGF EGF IL1B IL1B TNF TNF LOC100723623 LOC100723623 ANXA7 ANXA7 Anxa2 Anxa2 CCL5 CCL5 ANXA3 ANXA3 CCL2 CCL2 ANXA1 ANXA1 TRPV3 TRPV3 ANXA11 ANXA11 NGF NGF ANXA6 ANXA6 ATF3 ATF3 NRTN NRTN ARTN ARTN ANXA5 ANXA5 ASIC3 ASIC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
TAC1Substance P. (129 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
ANXA9Annexin. (345 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (289 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
ANXA4Annexin. (321 aa)
ANXA13Annexin. (315 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
LOC100723623Annexin. (327 aa)
ANXA7Annexin. (456 aa)
Anxa2Annexin. (339 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
ANXA3Annexin. (323 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (120 aa)
ANXA1Annexin. (346 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (789 aa)
ANXA11Annexin. (499 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. (308 aa)
ANXA6Annexin. (753 aa)
ATF3Activating transcription factor 3. (181 aa)
NRTNNeurturin. (197 aa)
ARTNArtemin. (223 aa)
ANXA5Annexin. (318 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (532 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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