STRINGSTRING
FGF2 FGF2 Gapdh Gapdh ANXA9 ANXA9 BDNF BDNF NES NES ANXA4 ANXA4 STAT3 STAT3 ANXA5 ANXA5 STAT4 STAT4 CNTF CNTF ANXA6 ANXA6 NGF NGF GFAP GFAP ANXA11 ANXA11 Stat5b Stat5b STAT2 STAT2 ANXA1 ANXA1 STAT6 STAT6 ANXA3 ANXA3 STAT1 STAT1 LOC100716811 LOC100716811 ANXA13 ANXA13 IL11 IL11 Anxa2 Anxa2 OTX2 OTX2 ANXA7 ANXA7 LOC100723623 LOC100723623 EGF EGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
GapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa)
ANXA9Annexin. (345 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (289 aa)
NESNestin; Belongs to the intermediate filament family. (1712 aa)
ANXA4Annexin. (321 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ANXA5Annexin. (318 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
CNTFCiliary neurotrophic factor. (192 aa)
ANXA6Annexin. (753 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. (308 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (431 aa)
ANXA11Annexin. (499 aa)
Stat5bSignal transducer and activator of transcription. (786 aa)
STAT2Signal transducer and activator of transcription. (853 aa)
ANXA1Annexin. (346 aa)
STAT6Signal transducer and activator of transcription. (838 aa)
ANXA3Annexin. (323 aa)
STAT1Signal transducer and activator of transcription. (799 aa)
LOC100716811Signal transducer and activator of transcription. (795 aa)
ANXA13Annexin. (315 aa)
IL11Interleukin 11. (199 aa)
Anxa2Annexin. (339 aa)
OTX2Orthodenticle homeobox 2. (289 aa)
ANXA7Annexin. (456 aa)
LOC100723623Annexin. (327 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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