STRINGSTRING
ANXA9 ANXA9 TLR7 TLR7 TFRC TFRC TLR3 TLR3 ANXA4 ANXA4 ANXA5 ANXA5 ANXA6 ANXA6 ANXA11 ANXA11 LAMP1 LAMP1 ANXA1 ANXA1 CCL2 CCL2 ANXA3 ANXA3 Cd4 Cd4 ANXA13 ANXA13 IL15 IL15 Anxa2 Anxa2 ANXA7 ANXA7 LOC100723623 LOC100723623 CD19 CD19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANXA9Annexin. (345 aa)
TLR7Toll like receptor 7. (1049 aa)
TFRCTransferrin receptor protein 1. (765 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
ANXA4Annexin. (321 aa)
ANXA5Annexin. (318 aa)
ANXA6Annexin. (753 aa)
ANXA11Annexin. (499 aa)
LAMP1Lysosomal associated membrane protein 1. (410 aa)
ANXA1Annexin. (346 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (120 aa)
ANXA3Annexin. (323 aa)
Cd4Uncharacterized protein. (523 aa)
ANXA13Annexin. (315 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa)
Anxa2Annexin. (339 aa)
ANXA7Annexin. (456 aa)
LOC100723623Annexin. (327 aa)
CD19B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] (536 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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