STRINGSTRING
SLC1A7 SLC1A7 LEP LEP INS INS STAT3 STAT3 SLC38A2 SLC38A2 ACTB ACTB LEPR LEPR JAK2 JAK2 SLC1A1 SLC1A1 STAT1 STAT1 SLC1A6 SLC1A6 SLC1A2 SLC1A2 SLC1A3 SLC1A3 SLC1A5 SLC1A5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC1A7Amino acid transporter. (574 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SLC38A2Solute carrier family 38 member 2. (509 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
LEPRLeptin receptor. (1174 aa)
JAK2Tyrosine-protein kinase. (1035 aa)
SLC1A1Amino acid transporter. (525 aa)
STAT1Signal transducer and activator of transcription. (799 aa)
SLC1A6Amino acid transporter. (560 aa)
SLC1A2Amino acid transporter. (573 aa)
SLC1A3Amino acid transporter. (542 aa)
SLC1A5Amino acid transporter. (471 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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