STRINGSTRING
FGF19 FGF19 FGF22 FGF22 FGF21 FGF21 FGF5 FGF5 TNF TNF NOS3 NOS3 CD151 CD151 FGF18 FGF18 VCAM1 VCAM1 FGF3 FGF3 FGF16 FGF16 Jaml Jaml CD81 CD81 FGF20 FGF20 ADAM17 ADAM17 TIAM1 TIAM1 FGF4 FGF4 FGF17 FGF17 PRKCA PRKCA RHOG RHOG FGF8 FGF8 FGF14 FGF14 SRC SRC RDX RDX FGF10 FGF10 ICAM2 ICAM2 SELL SELL FGF1 FGF1 VAMP3 VAMP3 FGF7 FGF7 Madcam1 Madcam1 CAV1 CAV1 FGF11 FGF11 FGF6 FGF6 FGF12 FGF12 VCL VCL CD9 CD9 Vamp2 Vamp2 Fgf9 Fgf9 MSN MSN FGF13 FGF13 Lsp1 Lsp1 EZR EZR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (160 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa)
CD151Tetraspanin. (201 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
VCAM1Vascular cell adhesion molecule 1. (732 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
JamlUncharacterized protein. (372 aa)
CD81Tetraspanin. (236 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa)
ADAM17ADAM metallopeptidase domain 17. (826 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
RHOGRas homolog family member G. (191 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
SRCTyrosine-protein kinase. (542 aa)
RDXRadixin. (604 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ICAM2Intercellular adhesion molecule 2. (278 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (365 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
Madcam1Ig-like domain-containing protein. (446 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
VCLVinculin. (1134 aa)
CD9Tetraspanin. (227 aa)
Vamp2V-SNARE coiled-coil homology domain-containing protein. (164 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (91 aa)
MSNMoesin. (577 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
Lsp1Uncharacterized protein. (82 aa)
EZREzrin. (586 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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