STRINGSTRING
APP APP OMG OMG PSEN2 PSEN2 IL1B IL1B LOC100723623 LOC100723623 ANXA7 ANXA7 SCN1A SCN1A IL18 IL18 Anxa2 Anxa2 IL2 IL2 ANXA13 ANXA13 IFNG IFNG STAT1 STAT1 ANXA3 ANXA3 ANXA1 ANXA1 TLR4 TLR4 ANXA11 ANXA11 MOG MOG TLR2 TLR2 ANXA6 ANXA6 IL6R IL6R ANXA5 ANXA5 SIRT2 SIRT2 SERPING1 SERPING1 MBP MBP ANXA4 ANXA4 IL4R IL4R IL1R1 IL1R1 PPIH PPIH IL1RN IL1RN ANXA9 ANXA9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
OMGOligodendrocyte myelin glycoprotein. (443 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
LOC100723623Annexin. (327 aa)
ANXA7Annexin. (456 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (189 aa)
Anxa2Annexin. (339 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
ANXA13Annexin. (315 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
STAT1Signal transducer and activator of transcription. (799 aa)
ANXA3Annexin. (323 aa)
ANXA1Annexin. (346 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
ANXA11Annexin. (499 aa)
MOGMyelin-oligodendrocyte glycoprotein; Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. Belongs to the immunoglobulin superfamily. BTN/MOG family. (244 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
ANXA6Annexin. (753 aa)
IL6RInterleukin 6 receptor. (450 aa)
ANXA5Annexin. (318 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (352 aa)
SERPING1SERPIN domain-containing protein; Belongs to the serpin family. (578 aa)
MBPMyelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity); Belongs to the myelin basic protein family. (194 aa)
ANXA4Annexin. (321 aa)
IL4RInterleukin 4 receptor. (829 aa)
IL1R1Interleukin 1 receptor type 1. (572 aa)
PPIHPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (177 aa)
IL1RNInterleukin-1. (176 aa)
ANXA9Annexin. (345 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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