STRINGSTRING
ANXA4 ANXA4 ANXA5 ANXA5 CNTF CNTF ANXA6 ANXA6 NEUROG1 NEUROG1 NGF NGF KIDINS220 KIDINS220 ANXA11 ANXA11 TLR4 TLR4 ANXA1 ANXA1 ANXA3 ANXA3 Trpa1 Trpa1 TAC1 TAC1 TRPV1 TRPV1 ANXA13 ANXA13 Anxa2 Anxa2 FGF2 FGF2 ANXA7 ANXA7 LOC100723623 LOC100723623 TRPV4 TRPV4 BDNF BDNF ANXA9 ANXA9 GDNF GDNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANXA4Annexin. (321 aa)
ANXA5Annexin. (318 aa)
CNTFCiliary neurotrophic factor. (192 aa)
ANXA6Annexin. (753 aa)
NEUROG1Neurogenin 1. (241 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. (308 aa)
KIDINS220Kinase D interacting substrate 220. (1791 aa)
ANXA11Annexin. (499 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
ANXA1Annexin. (346 aa)
ANXA3Annexin. (323 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
TAC1Substance P. (129 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
ANXA13Annexin. (315 aa)
Anxa2Annexin. (339 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
ANXA7Annexin. (456 aa)
LOC100723623Annexin. (327 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (289 aa)
ANXA9Annexin. (345 aa)
GDNFGlial cell derived neurotrophic factor. (210 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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