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PDE4D PDE4D GSTP1 GSTP1 HPGDS HPGDS ALG13 ALG13 ALDOC ALDOC GSTA4 GSTA4 PDE4A PDE4A ENPP1 ENPP1 ACOX1 ACOX1 PDE1B PDE1B ASAH2 ASAH2 PDE3B PDE3B ATG5 ATG5 LPIN1 LPIN1 NAGK NAGK SPHK1 SPHK1 MTOR MTOR AMPD2 AMPD2 PDE8A PDE8A LPIN2 LPIN2 ACSL3 ACSL3 CDIPT CDIPT PRPS1 PRPS1 PDE2A PDE2A KLRG1 KLRG1 SPHK2 SPHK2 KDSR KDSR GPD1L GPD1L ENPP4 ENPP4 ITPA ITPA ATG7 ATG7 GFPT1 GFPT1 PRPS2 PRPS2 ACTB ACTB SGPL1 SGPL1 ATG12 ATG12 GSTK1 GSTK1 CANT1 CANT1 CEPT1 CEPT1 IFNG IFNG PLB1 PLB1 PDE7A PDE7A GALC GALC NAMPT NAMPT PDE5A PDE5A ASAH1 ASAH1 GSTM1 GSTM1 CD44 CD44 LCK LCK Aldoa Aldoa NPL NPL ACSL5 ACSL5 ADK ADK ALG5 ALG5 DCK DCK Acsl1 Acsl1 AMPD1 AMPD1 ACSL4 ACSL4 GSTO1 GSTO1 GBA2 GBA2 AMPD3 AMPD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE4DPhosphodiesterase. (782 aa)
GSTP1Glutathione S-transferase pi 1. (210 aa)
HPGDSHematopoietic prostaglandin D synthase. (199 aa)
ALG13ALG13 UDP-N-acetylglucosaminyltransferase subunit. (1095 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
GSTA4Glutathione S-transferase alpha 4. (252 aa)
PDE4AcAMP-specific 3',5'-cyclic phosphodiesterase 4A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. (863 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (900 aa)
ACOX1Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (660 aa)
PDE1BPhosphodiesterase. (535 aa)
ASAH2Neutral ceramidase. (752 aa)
PDE3BPhosphodiesterase. (931 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
LPIN1Lipin 1. (899 aa)
NAGKN-acetylglucosamine kinase. (345 aa)
SPHK1Sphingosine kinase 1. (386 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (825 aa)
PDE8APhosphodiesterase. (826 aa)
LPIN2Lipin 2. (915 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
PRPS1Pribosyltran_N domain-containing protein. (318 aa)
PDE2APhosphodiesterase. (950 aa)
KLRG1Killer cell lectin like receptor G1. (191 aa)
SPHK2Sphingosine kinase 2. (655 aa)
KDSR3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
GPD1LGlycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
ENPP4Ectonucleotide pyrophosphatase/phosphodiesterase 4. (478 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (207 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
PRPS2Phosphoribosyl pyrophosphate synthetase 2. (318 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
GSTK1Glutathione S-transferase kappa. (226 aa)
CANT1Calcium activated nucleotidase 1. (433 aa)
CEPT1Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (416 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PLB1Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. (1453 aa)
PDE7APhosphodiesterase. (482 aa)
GALCGalactosylceramidase. (685 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (487 aa)
PDE5APhosphodiesterase. (863 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa)
GSTM1Glutathione S-transferase B; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. (222 aa)
CD44CD44 molecule (Indian blood group). (660 aa)
LCKTyrosine-protein kinase. (511 aa)
AldoaFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (416 aa)
NPLN-acetylneuraminate pyruvate lyase; Belongs to the DapA family. (320 aa)
ACSL5AMP-binding domain-containing protein. (682 aa)
ADKAdenosine kinase. (362 aa)
ALG5ALG5 dolichyl-phosphate beta-glucosyltransferase. (324 aa)
DCKDeoxycytidine kinase. (260 aa)
Acsl1Long-chain-fatty-acid--CoA ligase 1; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs); Belongs to the ATP-dependent AMP-binding enzyme family. (698 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (736 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (707 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (239 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (908 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (767 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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