STRINGSTRING
GOT2 GOT2 HTR1D HTR1D HTR1B HTR1B PVALB PVALB GABRG1 GABRG1 SLC1A1 SLC1A1 TAC1 TAC1 SLC1A7 SLC1A7 SLC6A4 SLC6A4 SST SST GOT1 GOT1 SLC1A2 SLC1A2 SLC1A3 SLC1A3 GABBR2 GABBR2 SLC1A5 SLC1A5 GABRA5 GABRA5 GABRG2 GABRG2 SLC1A6 SLC1A6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GOT2Aspartate aminotransferase. (430 aa)
HTR1D5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] (376 aa)
HTR1B5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa)
PVALBParvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (110 aa)
GABRG1Gamma-aminobutyric acid type A receptor gamma1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (384 aa)
SLC1A1Amino acid transporter. (525 aa)
TAC1Substance P. (129 aa)
SLC1A7Amino acid transporter. (574 aa)
SLC6A4Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner (By similarity); Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. (612 aa)
SSTSomatostatin. (116 aa)
GOT1Aspartate aminotransferase. (413 aa)
SLC1A2Amino acid transporter. (573 aa)
SLC1A3Amino acid transporter. (542 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (820 aa)
SLC1A5Amino acid transporter. (471 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
GABRG2Gamma-aminobutyric acid type A receptor gamma2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
SLC1A6Amino acid transporter. (560 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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