69 items (Cavia porcellus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
	GLS	Glutaminase. (649 aa)
	ALDOB	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	TPI1	Triosephosphate isomerase. (249 aa)
	TKTL1	Transketolase like 1. (597 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
	KHK	Ketohexokinase. (343 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (399 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (265 aa)
	Pdha1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	Aldoa	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (416 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	PDHB	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
	PGAM2	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2393 aa)
	ENO2	Enolase 2. (434 aa)
	Glud1	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (540 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2447 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	ACO1	Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
	OGDH	Oxoglutarate dehydrogenase. (1038 aa)
	PDHX	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (442 aa)
	SUCLG1	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
	G6PC3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
	FASN	Fatty acid synthase. (2530 aa)
	SLC25A1	Solute carrier family 25 member 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
	IDH3A	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (379 aa)
	Rpe	Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
	SLC16A1	Solute carrier family 16 member 1. (501 aa)
	PDK4	Protein-serine/threonine kinase. (412 aa)
	PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (650 aa)
	Gapdh	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
	GCK	Phosphotransferase. (414 aa)
	HNRNPA2B1	Heterogeneous nuclear ribonucleoprotein A2/B1. (369 aa)
	PGK1	Phosphoglycerate kinase. (417 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	PGAM1	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
	Ldhb	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1219 aa)
	ENO1	Alpha-enolase. (434 aa)
	FH	Fumarate hydratase. (508 aa)
	ACO2	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa)
	IDH3G	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa)
	PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (556 aa)
	PFKL	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (751 aa)
	TKTL2	Transketolase like 2. (627 aa)
	PDK2	Protein-serine/threonine kinase. (407 aa)
	Hnrnpa1	RRM domain-containing protein. (324 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (211 aa)
	KLF4	Kruppel like factor 4. (469 aa)
	IDH3B	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (383 aa)
	SLC2A5	Solute carrier family 2 member 5; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (501 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSCPOP00000005455	ENSCPOP00000004177	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.857
ACACA	ACLY	ENSCPOP00000005455	ENSCPOP00000026570	Acetyl-CoA carboxylase alpha.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.944
ACACA	DLAT	ENSCPOP00000005455	ENSCPOP00000032206	Acetyl-CoA carboxylase alpha.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.822
ACACA	FASN	ENSCPOP00000005455	ENSCPOP00000002086	Acetyl-CoA carboxylase alpha.	Fatty acid synthase.	0.973
ACACA	GAPDHS	ENSCPOP00000005455	ENSCPOP00000009590	Acetyl-CoA carboxylase alpha.	Glyceraldehyde-3-phosphate dehydrogenase.	0.448
ACACA	GLS	ENSCPOP00000005455	ENSCPOP00000011395	Acetyl-CoA carboxylase alpha.	Glutaminase.	0.606
ACACA	GOT1	ENSCPOP00000005455	ENSCPOP00000007755	Acetyl-CoA carboxylase alpha.	Aspartate aminotransferase.	0.606
ACACA	GOT2	ENSCPOP00000005455	ENSCPOP00000032571	Acetyl-CoA carboxylase alpha.	Aspartate aminotransferase.	0.606
ACACA	Glud1	ENSCPOP00000005455	ENSCPOP00000004647	Acetyl-CoA carboxylase alpha.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.805
ACACA	Ldhb	ENSCPOP00000005455	ENSCPOP00000027734	Acetyl-CoA carboxylase alpha.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.626
ACACA	PC	ENSCPOP00000005455	ENSCPOP00000025108	Acetyl-CoA carboxylase alpha.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.860
ACACA	PDHB	ENSCPOP00000005455	ENSCPOP00000006048	Acetyl-CoA carboxylase alpha.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.714
ACACA	PDHX	ENSCPOP00000005455	ENSCPOP00000002806	Acetyl-CoA carboxylase alpha.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.711
ACACA	PHGDH	ENSCPOP00000005455	ENSCPOP00000006066	Acetyl-CoA carboxylase alpha.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.418
ACACA	PKLR	ENSCPOP00000005455	ENSCPOP00000010073	Acetyl-CoA carboxylase alpha.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.708
ACACA	PKM	ENSCPOP00000005455	ENSCPOP00000008101	Acetyl-CoA carboxylase alpha.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.622
ACACA	PSAT1	ENSCPOP00000005455	ENSCPOP00000026951	Acetyl-CoA carboxylase alpha.	Phosphoserine aminotransferase.	0.723
ACACA	SLC25A1	ENSCPOP00000005455	ENSCPOP00000001585	Acetyl-CoA carboxylase alpha.	Solute carrier family 25 member 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.445
ACACA	SUCLG1	ENSCPOP00000005455	ENSCPOP00000002733	Acetyl-CoA carboxylase alpha.	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	0.809
ACACA	TKTL1	ENSCPOP00000005455	ENSCPOP00000010583	Acetyl-CoA carboxylase alpha.	Transketolase like 1.	0.435