STRINGSTRING
ALDH3B2 ALDH3B2 APOE APOE GAPDHS GAPDHS ALDH3A1 ALDH3A1 COX1 COX1 ND3 ND3 PINK1 PINK1 ALDH3B1 ALDH3B1 FIS1 FIS1 ALDH3A2 ALDH3A2 FUNDC1 FUNDC1 PRKCD PRKCD Aldh2 Aldh2 ULK1 ULK1 AMBRA1 AMBRA1 BECN1 BECN1 MFF MFF Gapdh Gapdh MFN2 MFN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALDH3B2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (298 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (399 aa)
ALDH3A1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (453 aa)
COX1Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (513 aa)
ND3NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (115 aa)
PINK1PTEN induced kinase 1. (574 aa)
ALDH3B1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (468 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
FUNDC1FUN14 domain containing 1. (155 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
Aldh2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (521 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1037 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1291 aa)
BECN1Beclin 1. (448 aa)
MFFMitochondrial fission factor. (354 aa)
GapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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