STRINGSTRING
ACAN ACAN GLRB GLRB LGI3 LGI3 WNT7A WNT7A BMP5 BMP5 BCAN BCAN HAPLN1 HAPLN1 SEMA4D SEMA4D PCDH15 PCDH15 PTPRM PTPRM NFASC NFASC LIN7C LIN7C ATP2A2 ATP2A2 ATP1B2 ATP1B2 YWHAZ YWHAZ ADAMTS4 ADAMTS4 ITGA6 ITGA6 CPLX1 CPLX1 KCNJ10 KCNJ10 CDH2 CDH2 ATP1B1 ATP1B1 NR4A3 NR4A3 CELSR3 CELSR3 KCNA2 KCNA2 COL14A1 COL14A1 TIMP4 TIMP4 KIRREL3 KIRREL3 ATP1A2 ATP1A2 OTOF OTOF CALB1 CALB1 WHRN WHRN EPHB1 EPHB1 KCNAB3 KCNAB3 ETF1 ETF1 SCN1A SCN1A CDH22 CDH22 IGSF11 IGSF11 CACNB3 CACNB3 SYT2 SYT2 SEMA3A SEMA3A GRIA3 GRIA3 HMGCR HMGCR CACNA1B CACNA1B ADAMTS20 ADAMTS20 CDH4 CDH4 LRRTM3 LRRTM3 CDH20 CDH20 GRIN2B GRIN2B SEMA5A SEMA5A ALDH1L1 ALDH1L1 BMP4 BMP4 DPYSL3 DPYSL3 SEMA3F SEMA3F CTNNA2 CTNNA2 CNTNAP1 CNTNAP1 ATP13A4 ATP13A4 SLC17A8 SLC17A8 ITGA8 ITGA8 ADAMTS16 ADAMTS16 EPHA4 EPHA4 CNTN5 CNTN5 PLXNA3 PLXNA3 OLIG2 OLIG2 ERC2 ERC2 RAMP3 RAMP3 SLC17A6 SLC17A6 GLRA1 GLRA1 ADAMTS18 ADAMTS18 GPR37 GPR37 SLC12A2 SLC12A2 CACNA1E CACNA1E CLCA1 CLCA1 EDNRB EDNRB ITGA2 ITGA2 HAPLN4 HAPLN4 UNC5A UNC5A Chrm3 Chrm3 DSG2 DSG2 ROBO2 ROBO2 GABRA2 GABRA2 ALDOC ALDOC PVALB PVALB Mobp Mobp CNTN4 CNTN4 CACNA1G CACNA1G CBLN1 CBLN1 L1CAM L1CAM SOX10 SOX10 UNC13B UNC13B VAMP1 VAMP1 CLDN11 CLDN11 AQP4 AQP4 ATP2B4 ATP2B4 DACT1 DACT1 EPS8 EPS8 SMPX SMPX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACANAggrecan. (2119 aa)
GLRBGlycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
LGI3Leucine rich repeat LGI family member 3. (548 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BCANBrevican. (899 aa)
HAPLN1Hyaluronan and proteoglycan link protein 1. (354 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (852 aa)
PCDH15Protocadherin related 15. (1913 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1445 aa)
NFASCNeurofascin. (1346 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (252 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif 4. (885 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1158 aa)
CPLX1Complexin 1. (134 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (306 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (633 aa)
CELSR3Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3301 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
COL14A1Collagen type XIV alpha 1 chain. (1800 aa)
TIMP4TIMP metallopeptidase inhibitor 4. (224 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (777 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
OTOFOtoferlin. (1980 aa)
CALB1Calbindin 1. (275 aa)
WHRNWhirlin. (916 aa)
EPHB1EPH receptor B1. (736 aa)
KCNAB3Potassium voltage-gated channel subfamily A regulatory beta subunit 3. (404 aa)
ETF1Eukaryotic translation termination factor 1. (437 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
CDH22Cadherin 22; Cadherins are calcium-dependent cell adhesion proteins. (731 aa)
IGSF11Immunoglobulin superfamily member 11. (420 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
SYT2Synaptotagmin 2. (421 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2270 aa)
ADAMTS20ADAM metallopeptidase with thrombospondin type 1 motif 20. (1817 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (895 aa)
LRRTM3Leucine rich repeat transmembrane neuronal 3. (581 aa)
CDH20Cadherin 20; Cadherins are calcium-dependent cell adhesion proteins. (801 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
SEMA5ASemaphorin 5A. (1073 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
BMP4Bone morphogenetic protein 4. (404 aa)
DPYSL3Dihydropyrimidinase like 3. (684 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
CTNNA2Catenin alpha 2. (954 aa)
CNTNAP1Contactin associated protein 1. (1374 aa)
ATP13A4Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1196 aa)
SLC17A8Solute carrier family 17 member 8. (476 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (932 aa)
EPHA4EPH receptor A4. (986 aa)
CNTN5Contactin 5. (1099 aa)
PLXNA3Plexin A3. (1872 aa)
OLIG2Oligodendrocyte transcription factor 2. (283 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (975 aa)
RAMP3Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). (192 aa)
SLC17A6Solute carrier family 17 member 6. (566 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18. (1219 aa)
GPR37G protein-coupled receptor 37. (606 aa)
SLC12A2Solute carrier family 12 member 2. (1136 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
CLCA1Chloride channel accessory 1. (913 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (415 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1156 aa)
HAPLN4Hyaluronan and proteoglycan link protein 4. (386 aa)
UNC5AUnc-5 netrin receptor A. (898 aa)
Chrm3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
DSG2Desmoglein 2. (985 aa)
ROBO2Roundabout guidance receptor 2. (1509 aa)
GABRA2Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PVALBParvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (110 aa)
MobpFYVE_2 domain-containing protein. (81 aa)
CNTN4Contactin 4. (1014 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
CBLN1Cerebellin 1 precursor. (105 aa)
L1CAML1 cell adhesion molecule. (1255 aa)
SOX10SRY-box transcription factor 10. (469 aa)
UNC13BUnc-13 homolog B. (1959 aa)
VAMP1Vesicle associated membrane protein 1. (118 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (551 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (821 aa)
SMPXSmall muscle protein X-linked. (86 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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