STRINGSTRING
COL1A1 COL1A1 NID1 NID1 ANXA1 ANXA1 TBX5 TBX5 FGF4 FGF4 SEMA3C SEMA3C ANXA3 ANXA3 SLIT3 SLIT3 FREM1 FREM1 FGF20 FGF20 ANXA13 ANXA13 FGF19 FGF19 FGF16 FGF16 SFTPD SFTPD FGF3 FGF3 HNF4A HNF4A Anxa2 Anxa2 FGF18 FGF18 PDGFRB PDGFRB FGF2 FGF2 FGF17 FGF17 ANXA7 ANXA7 LOC100723623 LOC100723623 GPLD1 GPLD1 FGF5 FGF5 FGF21 FGF21 FGF22 FGF22 EGFR EGFR FGF8 FGF8 FGF14 FGF14 ANXA11 ANXA11 ANXA6 ANXA6 SFTPA1 SFTPA1 FGF10 FGF10 ANXA5 ANXA5 WNT3A WNT3A FGF1 FGF1 ANXA4 ANXA4 FGF7 FGF7 NPNT NPNT FGF11 FGF11 FGF6 FGF6 FGF12 FGF12 SHH SHH Fgf9 Fgf9 LMNB1 LMNB1 ANXA9 ANXA9 FGF13 FGF13 WNT1 WNT1 COL4A5 COL4A5 THBS1 THBS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL1A1Collagen type I alpha 1 chain. (1454 aa)
NID1Nidogen 1. (1239 aa)
ANXA1Annexin. (346 aa)
TBX5T-box transcription factor 5. (518 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (787 aa)
ANXA3Annexin. (323 aa)
SLIT3Slit guidance ligand 3. (1517 aa)
FREM1FRAS1 related extracellular matrix 1. (2182 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa)
ANXA13Annexin. (315 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SFTPDSurfactant protein D. (347 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
Anxa2Annexin. (339 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ANXA7Annexin. (456 aa)
LOC100723623Annexin. (327 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (839 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (160 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
ANXA11Annexin. (499 aa)
ANXA6Annexin. (753 aa)
SFTPA1Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. (247 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ANXA5Annexin. (318 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
ANXA4Annexin. (321 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
NPNTNephronectin. (556 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (91 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (496 aa)
ANXA9Annexin. (345 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
COL4A5Collagen type IV alpha 5 chain. (1602 aa)
THBS1Thrombospondin 1. (1163 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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