(13 nodes) (2018) The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk. network (Cavia porcellus)

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Your Input:
	ZBTB44	Zinc finger and BTB domain containing 44. (572 aa)
	NOX3	NADPH oxidase 3. (568 aa)
	PTPN4	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (914 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (633 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	Sertad4	SERTA domain-containing protein. (140 aa)
	REN	Renin; Belongs to the peptidase A1 family. (403 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1018 aa)
	NBEAL1	Neurobeachin like 1. (2538 aa)
	DUOX2	Dual oxidase 2. (1517 aa)
	GCH1	GTP cyclohydrolase 1. (222 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUOX2	NOX3	ENSCPOP00000006547	ENSCPOP00000000902	Dual oxidase 2.	NADPH oxidase 3.	0.632
EDN1	INS	ENSCPOP00000028977	ENSCPOP00000026989	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.468
EDN1	REN	ENSCPOP00000028977	ENSCPOP00000016660	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Renin; Belongs to the peptidase A1 family.	0.576
IHH	NBEAL1	ENSCPOP00000030729	ENSCPOP00000007209	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Neurobeachin like 1.	0.527
IHH	PTPN4	ENSCPOP00000030729	ENSCPOP00000032308	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton.	0.536
IHH	Sertad4	ENSCPOP00000030729	ENSCPOP00000020951	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	SERTA domain-containing protein.	0.444
IHH	ZBTB44	ENSCPOP00000030729	ENSCPOP00000002871	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Zinc finger and BTB domain containing 44.	0.599
INS	EDN1	ENSCPOP00000026989	ENSCPOP00000028977	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.468
INS	REN	ENSCPOP00000026989	ENSCPOP00000016660	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Renin; Belongs to the peptidase A1 family.	0.733
NBEAL1	IHH	ENSCPOP00000007209	ENSCPOP00000030729	Neurobeachin like 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.527
NBEAL1	PTPN4	ENSCPOP00000007209	ENSCPOP00000032308	Neurobeachin like 1.	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton.	0.610
NBEAL1	Sertad4	ENSCPOP00000007209	ENSCPOP00000020951	Neurobeachin like 1.	SERTA domain-containing protein.	0.669
NBEAL1	ZBTB44	ENSCPOP00000007209	ENSCPOP00000002871	Neurobeachin like 1.	Zinc finger and BTB domain containing 44.	0.645
NOX3	DUOX2	ENSCPOP00000000902	ENSCPOP00000006547	NADPH oxidase 3.	Dual oxidase 2.	0.632
PTPN4	IHH	ENSCPOP00000032308	ENSCPOP00000030729	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.536
PTPN4	NBEAL1	ENSCPOP00000032308	ENSCPOP00000007209	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton.	Neurobeachin like 1.	0.610
PTPN4	Sertad4	ENSCPOP00000032308	ENSCPOP00000020951	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton.	SERTA domain-containing protein.	0.491
PTPN4	ZBTB44	ENSCPOP00000032308	ENSCPOP00000002871	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton.	Zinc finger and BTB domain containing 44.	0.564
REN	EDN1	ENSCPOP00000016660	ENSCPOP00000028977	Renin; Belongs to the peptidase A1 family.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.576
REN	INS	ENSCPOP00000016660	ENSCPOP00000026989	Renin; Belongs to the peptidase A1 family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.733