STRINGSTRING
CD19 CD19 Anxa2 Anxa2 FOXP3 FOXP3 ANXA13 ANXA13 Cd4 Cd4 STAT1 STAT1 ANXA3 ANXA3 STAT6 STAT6 ANXA1 ANXA1 ANXA11 ANXA11 BCL2 BCL2 ANXA6 ANXA6 ANXA5 ANXA5 ITGAM ITGAM BCHE BCHE ANXA7 ANXA7 LOC100723623 LOC100723623 IL1B IL1B CD3E CD3E ANXA9 ANXA9 Il4 Il4 ANXA4 ANXA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD19B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] (536 aa)
Anxa2Annexin. (339 aa)
FOXP3Forkhead box P3. (432 aa)
ANXA13Annexin. (315 aa)
Cd4Uncharacterized protein. (523 aa)
STAT1Signal transducer and activator of transcription. (799 aa)
ANXA3Annexin. (323 aa)
STAT6Signal transducer and activator of transcription. (838 aa)
ANXA1Annexin. (346 aa)
ANXA11Annexin. (499 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
ANXA6Annexin. (753 aa)
ANXA5Annexin. (318 aa)
ITGAMIntegrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] (1123 aa)
BCHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (602 aa)
ANXA7Annexin. (456 aa)
LOC100723623Annexin. (327 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CD3ECD3e molecule. (194 aa)
ANXA9Annexin. (345 aa)
Il4Interleukin-4. (144 aa)
ANXA4Annexin. (321 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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