STRINGSTRING
ULK1 ULK1 IL9 IL9 SLC25A48 SLC25A48 TLR4 TLR4 HDAC4 HDAC4 SLC1A1 SLC1A1 STAT1 STAT1 SLC11A1 SLC11A1 IFNG IFNG SLC1A7 SLC1A7 SLC1A2 SLC1A2 SLC1A3 SLC1A3 HDAC7 HDAC7 HDAC9 HDAC9 SLC1A5 SLC1A5 SLC1A6 SLC1A6 IL1B IL1B LUM LUM NOD2 NOD2 NOD1 NOD1 HDAC5 HDAC5 IL12RB1 IL12RB1 SLC6A3 SLC6A3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ULK1Unc-51 like autophagy activating kinase 1. (1037 aa)
IL9Interleukin 9. (130 aa)
SLC25A48Solute carrier family 25 member 48; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1078 aa)
SLC1A1Amino acid transporter. (525 aa)
STAT1Signal transducer and activator of transcription. (799 aa)
SLC11A1Solute carrier family 11 member 1. (541 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
SLC1A7Amino acid transporter. (574 aa)
SLC1A2Amino acid transporter. (573 aa)
SLC1A3Amino acid transporter. (542 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (997 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1046 aa)
SLC1A5Amino acid transporter. (471 aa)
SLC1A6Amino acid transporter. (560 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
LUMLumican. (340 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1018 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (873 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1137 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (714 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (28%) [HD]