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PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa) | ||||
SLC1A1 | Amino acid transporter. (525 aa) | ||||
APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa) | ||||
INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa) | ||||
SLC1A7 | Amino acid transporter. (574 aa) | ||||
SLC1A2 | Amino acid transporter. (573 aa) | ||||
SLC1A3 | Amino acid transporter. (542 aa) | ||||
SLC1A5 | Amino acid transporter. (471 aa) | ||||
SLC1A6 | Amino acid transporter. (560 aa) | ||||
IDE | Insulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa) |