node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | APP | ENSCPOP00000022236 | ENSCPOP00000020780 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.406 |
ACTB | GAPDHS | ENSCPOP00000022236 | ENSCPOP00000009590 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Glyceraldehyde-3-phosphate dehydrogenase. | 0.699 |
ACTB | Gapdh | ENSCPOP00000022236 | ENSCPOP00000032190 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.779 |
ACTB | SYP | ENSCPOP00000022236 | ENSCPOP00000027644 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Synaptophysin. | 0.421 |
ADAM10 | APLP2 | ENSCPOP00000009443 | ENSCPOP00000011030 | ADAM metallopeptidase domain 10. | Amyloid beta precursor like protein 2. | 0.629 |
ADAM10 | APP | ENSCPOP00000009443 | ENSCPOP00000020780 | ADAM metallopeptidase domain 10. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.823 |
AJAP1 | EN2 | ENSCPOP00000021430 | ENSCPOP00000020433 | Adherens junctions associated protein 1. | Homeobox protein engrailed-like. | 0.432 |
AJAP1 | ITM2B | ENSCPOP00000021430 | ENSCPOP00000027761 | Adherens junctions associated protein 1. | Integral membrane protein 2B. | 0.441 |
AJAP1 | NSG1 | ENSCPOP00000021430 | ENSCPOP00000022882 | Adherens junctions associated protein 1. | Neuronal vesicle trafficking associated 1. | 0.452 |
AJAP1 | PIANP | ENSCPOP00000021430 | ENSCPOP00000000306 | Adherens junctions associated protein 1. | PILR alpha associated neural protein. | 0.656 |
AJAP1 | SYT11 | ENSCPOP00000021430 | ENSCPOP00000004379 | Adherens junctions associated protein 1. | Synaptotagmin 11. | 0.420 |
APLP2 | ADAM10 | ENSCPOP00000011030 | ENSCPOP00000009443 | Amyloid beta precursor like protein 2. | ADAM metallopeptidase domain 10. | 0.629 |
APLP2 | APP | ENSCPOP00000011030 | ENSCPOP00000020780 | Amyloid beta precursor like protein 2. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.743 |
APLP2 | GAPDHS | ENSCPOP00000011030 | ENSCPOP00000009590 | Amyloid beta precursor like protein 2. | Glyceraldehyde-3-phosphate dehydrogenase. | 0.632 |
APLP2 | Gapdh | ENSCPOP00000011030 | ENSCPOP00000032190 | Amyloid beta precursor like protein 2. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.632 |
APLP2 | ITM2B | ENSCPOP00000011030 | ENSCPOP00000027761 | Amyloid beta precursor like protein 2. | Integral membrane protein 2B. | 0.546 |
APLP2 | KLC1 | ENSCPOP00000011030 | ENSCPOP00000017390 | Amyloid beta precursor like protein 2. | Kinesin light chain 1. | 0.509 |
APLP2 | PIANP | ENSCPOP00000011030 | ENSCPOP00000000306 | Amyloid beta precursor like protein 2. | PILR alpha associated neural protein. | 0.466 |
APLP2 | SYT11 | ENSCPOP00000011030 | ENSCPOP00000004379 | Amyloid beta precursor like protein 2. | Synaptotagmin 11. | 0.707 |
APP | ACTB | ENSCPOP00000020780 | ENSCPOP00000022236 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.406 |