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SLC25A42 SLC25A42 Gapdh Gapdh G6PC2 G6PC2 GCK GCK Timm13 Timm13 DHCR7 DHCR7 UGP2 UGP2 INS INS PC PC PHKA1 PHKA1 ENO1 ENO1 AQP4 AQP4 HMGCS1 HMGCS1 FH FH ACO2 ACO2 SLC5A10 SLC5A10 PDK1 PDK1 PYGB PYGB PFKL PFKL Lox Lox CS CS G6PC G6PC ENO3 ENO3 SLC2A2 SLC2A2 NDUFA9 NDUFA9 MDH2 MDH2 Sdha Sdha Aldoa Aldoa HMGCS2 HMGCS2 GBE1 GBE1 PYGL PYGL COX6B1 COX6B1 COX6A2 COX6A2 HMGCR HMGCR G6PC3 G6PC3 SORD SORD GYG1 GYG1 TKT TKT DLAT DLAT
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC25A42Solute carrier family 25 member 42; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
GapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
GCKPhosphotransferase. (414 aa)
Timm13zf-Tim10_DDP domain-containing protein; Belongs to the small Tim family. (95 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
UGP2UTP--glucose-1-phosphate uridylyltransferase. (508 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1219 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1237 aa)
ENO1Alpha-enolase. (434 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
FHFumarate hydratase. (508 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa)
SLC5A10Solute carrier family 5 member 10; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (597 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (751 aa)
LoxUncharacterized protein. (209 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
ENO3Enolase 3. (434 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
NDUFA9NADH:ubiquinone oxidoreductase subunit A9. (377 aa)
MDH2Malate dehydrogenase. (338 aa)
SdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (652 aa)
AldoaFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (416 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
GBE11,4-alpha-glucan branching enzyme 1. (668 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (867 aa)
COX6B1Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
COX6A2Cytochrome c oxidase subunit 6A, mitochondrial. (96 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
SORDSorbitol dehydrogenase. (357 aa)
GYG1Glycogenin 1. (342 aa)
TKTTransketolase. (592 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (650 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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