node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | Ocln | ENSCPOP00000022236 | ENSCPOP00000005207 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. | 0.503 |
ACTB | RDX | ENSCPOP00000022236 | ENSCPOP00000022333 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Radixin. | 0.887 |
ACTB | TLR4 | ENSCPOP00000022236 | ENSCPOP00000013667 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.456 |
CCL2 | CD44 | ENSCPOP00000012126 | ENSCPOP00000007016 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | CD44 molecule (Indian blood group). | 0.447 |
CCL2 | TLR4 | ENSCPOP00000012126 | ENSCPOP00000013667 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.583 |
CD44 | CCL2 | ENSCPOP00000007016 | ENSCPOP00000012126 | CD44 molecule (Indian blood group). | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | 0.447 |
CD44 | RDX | ENSCPOP00000007016 | ENSCPOP00000022333 | CD44 molecule (Indian blood group). | Radixin. | 0.962 |
CD44 | TLR4 | ENSCPOP00000007016 | ENSCPOP00000013667 | CD44 molecule (Indian blood group). | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.704 |
LAYN | RDX | ENSCPOP00000019338 | ENSCPOP00000022333 | Layilin. | Radixin. | 0.437 |
Ocln | ACTB | ENSCPOP00000005207 | ENSCPOP00000022236 | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.503 |
Ocln | TLR4 | ENSCPOP00000005207 | ENSCPOP00000013667 | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.684 |
RDX | ACTB | ENSCPOP00000022333 | ENSCPOP00000022236 | Radixin. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.887 |
RDX | CD44 | ENSCPOP00000022333 | ENSCPOP00000007016 | Radixin. | CD44 molecule (Indian blood group). | 0.962 |
RDX | LAYN | ENSCPOP00000022333 | ENSCPOP00000019338 | Radixin. | Layilin. | 0.437 |
TLR4 | ACTB | ENSCPOP00000013667 | ENSCPOP00000022236 | Toll like receptor 4; Belongs to the Toll-like receptor family. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.456 |
TLR4 | CCL2 | ENSCPOP00000013667 | ENSCPOP00000012126 | Toll like receptor 4; Belongs to the Toll-like receptor family. | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | 0.583 |
TLR4 | CD44 | ENSCPOP00000013667 | ENSCPOP00000007016 | Toll like receptor 4; Belongs to the Toll-like receptor family. | CD44 molecule (Indian blood group). | 0.704 |
TLR4 | Ocln | ENSCPOP00000013667 | ENSCPOP00000005207 | Toll like receptor 4; Belongs to the Toll-like receptor family. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. | 0.684 |