9 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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gene fusions

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Your Input:
	SLC1A6	Amino acid transporter. (560 aa)
	SLC1A5	Amino acid transporter. (471 aa)
	SLC1A3	Amino acid transporter. (542 aa)
	SLC1A2	Amino acid transporter. (573 aa)
	SLC1A7	Amino acid transporter. (574 aa)
	SLC1A1	Amino acid transporter. (525 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	PTGS2	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	IL1B	ENSCPOP00000022236	ENSCPOP00000001784	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.505
IL1B	ACTB	ENSCPOP00000001784	ENSCPOP00000022236	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.505
IL1B	PTGS2	ENSCPOP00000001784	ENSCPOP00000001794	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	0.897
PTGS2	IL1B	ENSCPOP00000001794	ENSCPOP00000001784	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.897
SLC1A1	SLC1A2	ENSCPOP00000011633	ENSCPOP00000007025	Amino acid transporter.	Amino acid transporter.	0.712
SLC1A1	SLC1A3	ENSCPOP00000011633	ENSCPOP00000006730	Amino acid transporter.	Amino acid transporter.	0.916
SLC1A1	SLC1A6	ENSCPOP00000011633	ENSCPOP00000001896	Amino acid transporter.	Amino acid transporter.	0.919
SLC1A1	SLC1A7	ENSCPOP00000011633	ENSCPOP00000009609	Amino acid transporter.	Amino acid transporter.	0.912
SLC1A2	SLC1A1	ENSCPOP00000007025	ENSCPOP00000011633	Amino acid transporter.	Amino acid transporter.	0.712
SLC1A2	SLC1A3	ENSCPOP00000007025	ENSCPOP00000006730	Amino acid transporter.	Amino acid transporter.	0.794
SLC1A2	SLC1A6	ENSCPOP00000007025	ENSCPOP00000001896	Amino acid transporter.	Amino acid transporter.	0.715
SLC1A2	SLC1A7	ENSCPOP00000007025	ENSCPOP00000009609	Amino acid transporter.	Amino acid transporter.	0.799
SLC1A3	SLC1A1	ENSCPOP00000006730	ENSCPOP00000011633	Amino acid transporter.	Amino acid transporter.	0.916
SLC1A3	SLC1A2	ENSCPOP00000006730	ENSCPOP00000007025	Amino acid transporter.	Amino acid transporter.	0.794
SLC1A3	SLC1A6	ENSCPOP00000006730	ENSCPOP00000001896	Amino acid transporter.	Amino acid transporter.	0.910
SLC1A3	SLC1A7	ENSCPOP00000006730	ENSCPOP00000009609	Amino acid transporter.	Amino acid transporter.	0.911
SLC1A6	SLC1A1	ENSCPOP00000001896	ENSCPOP00000011633	Amino acid transporter.	Amino acid transporter.	0.919
SLC1A6	SLC1A2	ENSCPOP00000001896	ENSCPOP00000007025	Amino acid transporter.	Amino acid transporter.	0.715
SLC1A6	SLC1A3	ENSCPOP00000001896	ENSCPOP00000006730	Amino acid transporter.	Amino acid transporter.	0.910
SLC1A6	SLC1A7	ENSCPOP00000001896	ENSCPOP00000009609	Amino acid transporter.	Amino acid transporter.	0.912