STRINGSTRING
ITGAM ITGAM ANXA5 ANXA5 ACTB ACTB ANXA6 ANXA6 DPH1 DPH1 ANXA11 ANXA11 PLAT PLAT CD55 CD55 CSF2 CSF2 DPH6 DPH6 LEPR LEPR ANXA1 ANXA1 ANXA3 ANXA3 TRHR TRHR ANXA13 ANXA13 CD63 CD63 USP48 USP48 CD44 CD44 DPH5 DPH5 DPH2 DPH2 Anxa2 Anxa2 FCGR2 FCGR2 ANXA7 ANXA7 LOC100723623 LOC100723623 CD46 CD46 DPH7 DPH7 ANXA9 ANXA9 CD9 CD9 CXCL1 CXCL1 CD47 CD47 C5AR1 C5AR1 ANXA4 ANXA4 DPH3 DPH3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGAMIntegrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] (1123 aa)
ANXA5Annexin. (318 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ANXA6Annexin. (753 aa)
DPH12-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (438 aa)
ANXA11Annexin. (499 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (559 aa)
CD55Complement decay-accelerating factor; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and [...] (446 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (145 aa)
DPH6Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. (221 aa)
LEPRLeptin receptor. (1174 aa)
ANXA1Annexin. (346 aa)
ANXA3Annexin. (323 aa)
TRHRThyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (393 aa)
ANXA13Annexin. (315 aa)
CD63Tetraspanin. (238 aa)
USP48Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (1045 aa)
CD44CD44 molecule (Indian blood group). (660 aa)
DPH5Diphthamide biosynthesis 5. (279 aa)
DPH22-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (489 aa)
Anxa2Annexin. (339 aa)
FCGR2Low affinity immunoglobulin gamma Fc region receptor II; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. (341 aa)
ANXA7Annexin. (456 aa)
LOC100723623Annexin. (327 aa)
CD46Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (387 aa)
DPH7Diphthamide biosynthesis 7. (446 aa)
ANXA9Annexin. (345 aa)
CD9Tetraspanin. (227 aa)
CXCL1Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (118 aa)
CD47CD47 molecule. (321 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity); Belongs to the G-protein coupled receptor 1 family. (345 aa)
ANXA4Annexin. (321 aa)
DPH3Diphthamide biosynthesis 3. (82 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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