STRINGSTRING
RARA RARA NES NES ITGAM ITGAM KL KL SYN1 SYN1 BDNF BDNF SLC1A1 SLC1A1 SLC38A3 SLC38A3 SLC1A7 SLC1A7 SLC1A2 SLC1A2 XBP1 XBP1 SLC1A3 SLC1A3 SLC1A5 SLC1A5 SLC1A6 SLC1A6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RARARetinoic acid receptor alpha. (462 aa)
NESNestin; Belongs to the intermediate filament family. (1712 aa)
ITGAMIntegrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] (1123 aa)
KLKlotho. (760 aa)
SYN1Synapsin I. (690 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (289 aa)
SLC1A1Amino acid transporter. (525 aa)
SLC38A3Solute carrier family 38 member 3. (503 aa)
SLC1A7Amino acid transporter. (574 aa)
SLC1A2Amino acid transporter. (573 aa)
XBP1X-box binding protein 1. (268 aa)
SLC1A3Amino acid transporter. (542 aa)
SLC1A5Amino acid transporter. (471 aa)
SLC1A6Amino acid transporter. (560 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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