STRINGSTRING
ANXA1 ANXA1 GPC1 GPC1 EGF EGF GPC4 GPC4 LOC100723623 LOC100723623 ANXA7 ANXA7 VTN VTN IL18 IL18 C1QL3 C1QL3 THBS4 THBS4 HYAL2 HYAL2 Anxa2 Anxa2 PAX6 PAX6 TGFB2 TGFB2 SERPINB6 SERPINB6 ACAN ACAN PTN PTN ANXA13 ANXA13 MAG MAG KNG1 KNG1 ANXA3 ANXA3 TGM5 TGM5 HYAL4 HYAL4 GSK3B GSK3B NID1 NID1 TLR4 TLR4 H0VT19_CAVPO H0VT19_CAVPO HYAL1 HYAL1 EPHA3 EPHA3 SP8 SP8 ANXA11 ANXA11 GFAP GFAP LOC100724497 LOC100724497 HYAL3 HYAL3 ANXA6 ANXA6 ANXA5 ANXA5 WNT3A WNT3A STAT3 STAT3 TGM1 TGM1 ANXA4 ANXA4 NES NES S100B S100B INS INS TGFB3 TGFB3 EGFR EGFR PLXNB2 PLXNB2 Meis2 Meis2 RELN RELN HAPLN1 HAPLN1 LMNB1 LMNB1 ANXA9 ANXA9 Gapdh Gapdh DCX DCX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANXA1Annexin. (346 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (555 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (547 aa)
LOC100723623Annexin. (327 aa)
ANXA7Annexin. (456 aa)
VTNSMB domain-containing protein. (482 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (189 aa)
C1QL3Complement C1q like 3. (234 aa)
THBS4Thrombospondin 4. (958 aa)
HYAL2Hyaluronidase. (471 aa)
Anxa2Annexin. (339 aa)
PAX6Paired box 6. (436 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
SERPINB6Serpin B6; Belongs to the serpin family. (378 aa)
ACANAggrecan. (2119 aa)
PTNPleiotrophin. (168 aa)
ANXA13Annexin. (315 aa)
MAGMyelin associated glycoprotein. (592 aa)
KNG1Kininogen 1. (625 aa)
ANXA3Annexin. (323 aa)
TGM5Transglutaminase 5. (719 aa)
HYAL4Hyaluronidase. (486 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
NID1Nidogen 1. (1239 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
H0VT19_CAVPOTGc domain-containing protein. (700 aa)
HYAL1Hyaluronidase. (449 aa)
EPHA3EPH receptor A3. (933 aa)
SP8Sp8 transcription factor. (463 aa)
ANXA11Annexin. (499 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (431 aa)
LOC100724497Hyaluronidase. (478 aa)
HYAL3Hyaluronidase. (412 aa)
ANXA6Annexin. (753 aa)
ANXA5Annexin. (318 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TGM1Transglutaminase 1. (819 aa)
ANXA4Annexin. (321 aa)
NESNestin; Belongs to the intermediate filament family. (1712 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
PLXNB2Plexin B2. (1845 aa)
Meis2Meis homeobox 2. (477 aa)
RELNReelin. (3423 aa)
HAPLN1Hyaluronan and proteoglycan link protein 1. (354 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (496 aa)
ANXA9Annexin. (345 aa)
GapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa)
DCXDoublecortin. (366 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.