STRINGSTRING
TLR4 TLR4 ANXA1 ANXA1 ANXA3 ANXA3 IFNG IFNG TRPM5 TRPM5 Anxa2 Anxa2 ANXA13 ANXA13 IL1B IL1B TNF TNF LOC100723623 LOC100723623 ANXA7 ANXA7 RPL13A RPL13A ANXA9 ANXA9 TRPV4 TRPV4 INS INS ANXA4 ANXA4 ANXA5 ANXA5 ANXA6 ANXA6 TXNIP TXNIP BCL2 BCL2 H0W1R6_CAVPO H0W1R6_CAVPO ANXA11 ANXA11 TGM2 TGM2 Txn Txn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
ANXA1Annexin. (346 aa)
ANXA3Annexin. (323 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1159 aa)
Anxa2Annexin. (339 aa)
ANXA13Annexin. (315 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
LOC100723623Annexin. (327 aa)
ANXA7Annexin. (456 aa)
RPL13ARibosomal protein L13a; Belongs to the universal ribosomal protein uL13 family. (203 aa)
ANXA9Annexin. (345 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ANXA4Annexin. (321 aa)
ANXA5Annexin. (318 aa)
ANXA6Annexin. (753 aa)
TXNIPThioredoxin interacting protein. (392 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
H0W1R6_CAVPOThioredoxin; Belongs to the thioredoxin family. (106 aa)
ANXA11Annexin. (499 aa)
TGM2TGc domain-containing protein. (735 aa)
TxnThioredoxin; Belongs to the thioredoxin family. (105 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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