STRINGSTRING
WT1 WT1 MAP4K4 MAP4K4 PKP2 PKP2 Casp3 Casp3 ACTN2 ACTN2 NFATC4 NFATC4 TBX20 TBX20 KLF4 KLF4 KCNQ1 KCNQ1 SRF SRF PRDM16 PRDM16 TNNI3 TNNI3 NBR1 NBR1 SRC SRC PTPN1 PTPN1 CACNA1C CACNA1C MYH10 MYH10 TGFB3 TGFB3 RYR2 RYR2 FLNC FLNC Sirpa Sirpa Kcnj2 Kcnj2 RHOA RHOA CASQ2 CASQ2 TPM1 TPM1 ACTC1 ACTC1 DMD DMD DSP DSP TGFB2 TGFB2 BAG3 BAG3 MYH7 MYH7 VCAM1 VCAM1 ISL1 ISL1 PPARG PPARG SCN5A SCN5A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WT1WT1 transcription factor. (320 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1198 aa)
PKP2Plakophilin 2. (835 aa)
Casp3CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (165 aa)
ACTN2Actinin alpha 2. (894 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
TBX20T-box transcription factor 20. (446 aa)
KLF4Kruppel like factor 4. (469 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (671 aa)
SRFSerum response factor. (461 aa)
PRDM16PR/SET domain 16. (1265 aa)
TNNI3Troponin I3, cardiac type. (211 aa)
NBR1NBR1 autophagy cargo receptor. (993 aa)
SRCTyrosine-protein kinase. (542 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (432 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RYR2Ryanodine receptor 2. (4910 aa)
FLNCFilamin C. (2726 aa)
SirpaIg-like domain-containing protein. (292 aa)
Kcnj2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...] (427 aa)
RHOARas homolog family member A. (193 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (408 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (288 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
DMDDystrophin. (3613 aa)
DSPDesmoplakin. (2805 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
BAG3BCL2 associated athanogene 3. (572 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1949 aa)
VCAM1Vascular cell adhesion molecule 1. (732 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.