STRINGSTRING
ITGAM ITGAM STAT3 STAT3 CD40 CD40 RELB RELB SCIMP SCIMP RDX RDX TRAF5 TRAF5 SRC SRC MYD88 MYD88 TRAF4 TRAF4 BCL2 BCL2 RELA RELA CSF2 CSF2 TLR4 TLR4 JAK2 JAK2 INSR INSR STAT1 STAT1 IL21 IL21 Cd4 Cd4 SPHK1 SPHK1 CASP9 CASP9 REL REL MTOR MTOR IFNG IFNG HBEGF HBEGF PCNA PCNA FGFR1 FGFR1 JAK1 JAK1 FGF2 FGF2 CD69 CD69 ZAP70 ZAP70 TRAF6 TRAF6 TYK2 TYK2 IL1B IL1B CALR CALR PXN PXN EZR EZR FGFR4 FGFR4 MSN MSN RHOA RHOA TRAF3 TRAF3 TRAF1 TRAF1 FGFR2 FGFR2 TRAF2 TRAF2 JAK3 JAK3 FGFR3 FGFR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGAMIntegrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] (1123 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CD40CD40 molecule. (285 aa)
RELBRELB proto-oncogene, NF-kB subunit. (554 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (153 aa)
RDXRadixin. (604 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (565 aa)
SRCTyrosine-protein kinase. (542 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (294 aa)
TRAF4TNF receptor-associated factor. (470 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (145 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
JAK2Tyrosine-protein kinase. (1035 aa)
INSRTyrosine-protein kinase receptor. (1371 aa)
STAT1Signal transducer and activator of transcription. (799 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
Cd4Uncharacterized protein. (523 aa)
SPHK1Sphingosine kinase 1. (386 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (447 aa)
RELREL proto-oncogene, NF-kB subunit. (601 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
CD69CD69 molecule. (199 aa)
ZAP70Tyrosine-protein kinase. (551 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
TYK2Tyrosine-protein kinase. (1174 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CALRCalreticulin. (417 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (588 aa)
EZREzrin. (586 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
MSNMoesin. (577 aa)
RHOARas homolog family member A. (193 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
TRAF1TNF receptor-associated factor. (416 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
JAK3Tyrosine-protein kinase. (1078 aa)
FGFR3Fibroblast growth factor receptor. (801 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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