31 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	ERC2	ELKS/RAB6-interacting/CAST family member 2. (975 aa)
	FUS	FUS RNA binding protein. (490 aa)
	TANC2	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2. (2013 aa)
	SYP	Synaptophysin. (312 aa)
	FRMPD4	FERM and PDZ domain containing 4. (1325 aa)
	EWSR1	EWS RNA binding protein 1. (653 aa)
	CHMP2B	Charged multivesicular body protein 2B. (213 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
	GABRB1	Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (419 aa)
	PVALB	Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (110 aa)
	CTNND2	Catenin delta 2. (1098 aa)
	IPO4	Importin 4. (1079 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
	ILF3	Interleukin enhancer binding factor 3. (895 aa)
	GPHN	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (709 aa)
	Mapt	Microtubule-associated protein. (370 aa)
	EXOSC10	Exosome component 10. (901 aa)
	GRID2	Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
	HTR3A	5-hydroxytryptamine receptor 3A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand- gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. (456 aa)
	SST	Somatostatin. (116 aa)
	C9orf72	C9orf72-SMCR8 complex subunit. (481 aa)
	GRN	Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule str [...] (605 aa)
	HNRNPL	Heterogeneous nuclear ribonucleoprotein L. (586 aa)
	GABRA1	Gamma-aminobutyric acid type A receptor alpha1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
	LRFN5	Leucine rich repeat and fibronectin type III domain containing 5. (719 aa)
	RBM3	RNA binding motif protein 3. (159 aa)
	TNPO1	Transportin 1. (813 aa)
	SYNGAP1	Synaptic Ras GTPase activating protein 1. (1284 aa)
	DDX39B	DExD-box helicase 39B. (428 aa)
	GABRA3	Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (505 aa)
	TBP	TATA-box binding protein. (321 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C9orf72	CHMP2B	ENSCPOP00000008502	ENSCPOP00000023486	C9orf72-SMCR8 complex subunit.	Charged multivesicular body protein 2B.	0.694
C9orf72	FUS	ENSCPOP00000008502	ENSCPOP00000028839	C9orf72-SMCR8 complex subunit.	FUS RNA binding protein.	0.746
C9orf72	GRN	ENSCPOP00000008502	ENSCPOP00000007890	C9orf72-SMCR8 complex subunit.	Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule str [...]	0.698
C9orf72	Mapt	ENSCPOP00000008502	ENSCPOP00000011723	C9orf72-SMCR8 complex subunit.	Microtubule-associated protein.	0.609
C9orf72	SOD1	ENSCPOP00000008502	ENSCPOP00000012815	C9orf72-SMCR8 complex subunit.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.	0.568
C9orf72	SST	ENSCPOP00000008502	ENSCPOP00000008673	C9orf72-SMCR8 complex subunit.	Somatostatin.	0.611
CHMP2B	C9orf72	ENSCPOP00000023486	ENSCPOP00000008502	Charged multivesicular body protein 2B.	C9orf72-SMCR8 complex subunit.	0.694
CHMP2B	FUS	ENSCPOP00000023486	ENSCPOP00000028839	Charged multivesicular body protein 2B.	FUS RNA binding protein.	0.497
CHMP2B	GRN	ENSCPOP00000023486	ENSCPOP00000007890	Charged multivesicular body protein 2B.	Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule str [...]	0.582
CHMP2B	Mapt	ENSCPOP00000023486	ENSCPOP00000011723	Charged multivesicular body protein 2B.	Microtubule-associated protein.	0.455
CTNND2	LRFN5	ENSCPOP00000016210	ENSCPOP00000004789	Catenin delta 2.	Leucine rich repeat and fibronectin type III domain containing 5.	0.525
CTNND2	TANC2	ENSCPOP00000016210	ENSCPOP00000028352	Catenin delta 2.	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2.	0.402
DDX39B	EWSR1	ENSCPOP00000002121	ENSCPOP00000024424	DExD-box helicase 39B.	EWS RNA binding protein 1.	0.567
DDX39B	EXOSC10	ENSCPOP00000002121	ENSCPOP00000031644	DExD-box helicase 39B.	Exosome component 10.	0.871
DDX39B	FRMPD4	ENSCPOP00000002121	ENSCPOP00000025673	DExD-box helicase 39B.	FERM and PDZ domain containing 4.	0.509
DDX39B	FUS	ENSCPOP00000002121	ENSCPOP00000028839	DExD-box helicase 39B.	FUS RNA binding protein.	0.516
DDX39B	GABRB1	ENSCPOP00000002121	ENSCPOP00000022135	DExD-box helicase 39B.	Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.400
DDX39B	HNRNPL	ENSCPOP00000002121	ENSCPOP00000006895	DExD-box helicase 39B.	Heterogeneous nuclear ribonucleoprotein L.	0.824
DDX39B	ILF3	ENSCPOP00000002121	ENSCPOP00000012364	DExD-box helicase 39B.	Interleukin enhancer binding factor 3.	0.868
DDX39B	IPO4	ENSCPOP00000002121	ENSCPOP00000013321	DExD-box helicase 39B.	Importin 4.	0.539