(11 nodes) (2021) Effects of low-dose X-ray medical diagnostics on female gonads: Insights from large animal oocytes and human ovaries as complementary models. network (Cavia porcellus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	Gapdh	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa)
	AMH	Anti-Mullerian hormone. (560 aa)
	BCL2	BCL2 apoptosis regulator. (183 aa)
	HYAL1	Hyaluronidase. (449 aa)
	HYAL4	Hyaluronidase. (486 aa)
	IGF2	Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (237 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (399 aa)
	HYAL2	Hyaluronidase. (471 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	HYAL3	Hyaluronidase. (412 aa)
	LOC100724497	Hyaluronidase. (478 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	GAPDHS	ENSCPOP00000016923	ENSCPOP00000009590	BCL2 apoptosis regulator.	Glyceraldehyde-3-phosphate dehydrogenase.	0.486
BCL2	Gapdh	ENSCPOP00000016923	ENSCPOP00000032190	BCL2 apoptosis regulator.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.659
BCL2	INS	ENSCPOP00000016923	ENSCPOP00000026989	BCL2 apoptosis regulator.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.544
GAPDHS	BCL2	ENSCPOP00000009590	ENSCPOP00000016923	Glyceraldehyde-3-phosphate dehydrogenase.	BCL2 apoptosis regulator.	0.486
GAPDHS	Gapdh	ENSCPOP00000009590	ENSCPOP00000032190	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.830
GAPDHS	INS	ENSCPOP00000009590	ENSCPOP00000026989	Glyceraldehyde-3-phosphate dehydrogenase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.535
Gapdh	BCL2	ENSCPOP00000032190	ENSCPOP00000016923	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	BCL2 apoptosis regulator.	0.659
Gapdh	GAPDHS	ENSCPOP00000032190	ENSCPOP00000009590	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.830
Gapdh	HYAL3	ENSCPOP00000032190	ENSCPOP00000020447	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Hyaluronidase.	0.413
Gapdh	INS	ENSCPOP00000032190	ENSCPOP00000026989	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.686
HYAL1	HYAL2	ENSCPOP00000014002	ENSCPOP00000004720	Hyaluronidase.	Hyaluronidase.	0.634
HYAL1	HYAL3	ENSCPOP00000014002	ENSCPOP00000020447	Hyaluronidase.	Hyaluronidase.	0.699
HYAL1	HYAL4	ENSCPOP00000014002	ENSCPOP00000012239	Hyaluronidase.	Hyaluronidase.	0.630
HYAL1	INS	ENSCPOP00000014002	ENSCPOP00000026989	Hyaluronidase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.595
HYAL1	LOC100724497	ENSCPOP00000014002	ENSCPOP00000020159	Hyaluronidase.	Hyaluronidase.	0.620
HYAL2	HYAL1	ENSCPOP00000004720	ENSCPOP00000014002	Hyaluronidase.	Hyaluronidase.	0.634
HYAL2	HYAL3	ENSCPOP00000004720	ENSCPOP00000020447	Hyaluronidase.	Hyaluronidase.	0.459
HYAL2	INS	ENSCPOP00000004720	ENSCPOP00000026989	Hyaluronidase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.532
HYAL3	Gapdh	ENSCPOP00000020447	ENSCPOP00000032190	Hyaluronidase.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.413
HYAL3	HYAL1	ENSCPOP00000020447	ENSCPOP00000014002	Hyaluronidase.	Hyaluronidase.	0.699