STRINGSTRING
HTT HTT IL1B IL1B SLC1A6 SLC1A6 SLC1A5 SLC1A5 SLC1A3 SLC1A3 SLC1A2 SLC1A2 SLC1A7 SLC1A7 KYNU KYNU SLC1A1 SLC1A1 QPRT QPRT HMOX1 HMOX1 STAT3 STAT3 IDO1 IDO1 GPR35 GPR35 SNCA SNCA IDO2 IDO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HTTHuntingtin. (3133 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
SLC1A6Amino acid transporter. (560 aa)
SLC1A5Amino acid transporter. (471 aa)
SLC1A3Amino acid transporter. (542 aa)
SLC1A2Amino acid transporter. (573 aa)
SLC1A7Amino acid transporter. (574 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (466 aa)
SLC1A1Amino acid transporter. (525 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (295 aa)
HMOX1Heme oxygenase 1. (297 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (405 aa)
GPR35G protein-coupled receptor 35; Belongs to the G-protein coupled receptor 1 family. (327 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
IDO2Indoleamine 2,3-dioxygenase 2. (359 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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