node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPR35 | IDO2 | ENSCPOP00000025861 | ENSCPOP00000030354 | G protein-coupled receptor 35; Belongs to the G-protein coupled receptor 1 family. | Indoleamine 2,3-dioxygenase 2. | 0.500 |
HMOX1 | IL1B | ENSCPOP00000019892 | ENSCPOP00000001784 | Heme oxygenase 1. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.633 |
HMOX1 | STAT3 | ENSCPOP00000019892 | ENSCPOP00000025514 | Heme oxygenase 1. | Signal transducer and activator of transcription. | 0.574 |
HTT | SLC1A2 | ENSCPOP00000024302 | ENSCPOP00000007025 | Huntingtin. | Amino acid transporter. | 0.423 |
HTT | SNCA | ENSCPOP00000024302 | ENSCPOP00000026441 | Huntingtin. | Alpha-synuclein; Belongs to the synuclein family. | 0.836 |
IDO1 | IDO2 | ENSCPOP00000025523 | ENSCPOP00000030354 | Indoleamine 2,3-dioxygenase 1. | Indoleamine 2,3-dioxygenase 2. | 0.803 |
IDO1 | IL1B | ENSCPOP00000025523 | ENSCPOP00000001784 | Indoleamine 2,3-dioxygenase 1. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.456 |
IDO1 | KYNU | ENSCPOP00000025523 | ENSCPOP00000010088 | Indoleamine 2,3-dioxygenase 1. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.931 |
IDO1 | QPRT | ENSCPOP00000025523 | ENSCPOP00000014786 | Indoleamine 2,3-dioxygenase 1. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.578 |
IDO2 | GPR35 | ENSCPOP00000030354 | ENSCPOP00000025861 | Indoleamine 2,3-dioxygenase 2. | G protein-coupled receptor 35; Belongs to the G-protein coupled receptor 1 family. | 0.500 |
IDO2 | IDO1 | ENSCPOP00000030354 | ENSCPOP00000025523 | Indoleamine 2,3-dioxygenase 2. | Indoleamine 2,3-dioxygenase 1. | 0.803 |
IDO2 | KYNU | ENSCPOP00000030354 | ENSCPOP00000010088 | Indoleamine 2,3-dioxygenase 2. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.974 |
IDO2 | QPRT | ENSCPOP00000030354 | ENSCPOP00000014786 | Indoleamine 2,3-dioxygenase 2. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.665 |
IL1B | HMOX1 | ENSCPOP00000001784 | ENSCPOP00000019892 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Heme oxygenase 1. | 0.633 |
IL1B | IDO1 | ENSCPOP00000001784 | ENSCPOP00000025523 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Indoleamine 2,3-dioxygenase 1. | 0.456 |
IL1B | STAT3 | ENSCPOP00000001784 | ENSCPOP00000025514 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Signal transducer and activator of transcription. | 0.812 |
KYNU | IDO1 | ENSCPOP00000010088 | ENSCPOP00000025523 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | Indoleamine 2,3-dioxygenase 1. | 0.931 |
KYNU | IDO2 | ENSCPOP00000010088 | ENSCPOP00000030354 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | Indoleamine 2,3-dioxygenase 2. | 0.974 |
KYNU | QPRT | ENSCPOP00000010088 | ENSCPOP00000014786 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.841 |
QPRT | IDO1 | ENSCPOP00000014786 | ENSCPOP00000025523 | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | Indoleamine 2,3-dioxygenase 1. | 0.578 |