STRINGSTRING
ADIPOQ ADIPOQ LAMTOR3 LAMTOR3 LAMP2 LAMP2 NDUFB4 NDUFB4 NDUFA4 NDUFA4 CDC42 CDC42 ITGB1 ITGB1 MYH6 MYH6 ANXA9 ANXA9 Gapdh Gapdh RAB7A RAB7A STX17 STX17 DCN DCN MYH7 MYH7 EHD1 EHD1 TOM1 TOM1 ATP6V1D ATP6V1D ANXA13 ANXA13 DYSF DYSF RILP RILP CTSS CTSS GAPDHS GAPDHS PLB1 PLB1 UQCR10 UQCR10 PAM PAM CTSA CTSA ANXA3 ANXA3 CYC1 CYC1 ACP2 ACP2 EEA1 EEA1 ANXA1 ANXA1 CLU CLU NPPA NPPA EHD2 EHD2 ANXA11 ANXA11 TNNT2 TNNT2 MAN2B1 MAN2B1 UQCRQ UQCRQ LAMTOR5 LAMTOR5 ANXA6 ANXA6 RAB1A RAB1A ANXA5 ANXA5 LAMTOR1 LAMTOR1 FLOT1 FLOT1 LAMTOR2 LAMTOR2 VPS29 VPS29 LRP1 LRP1 ANXA4 ANXA4 VAMP8 VAMP8 ACE ACE LOC100723623 LOC100723623 ANXA7 ANXA7 RAB6A RAB6A GBA GBA CANX CANX VPS35 VPS35 HSPA8 HSPA8 APOE APOE MYH7B MYH7B AP2A1 AP2A1 NDUFB9 NDUFB9 Anxa2 Anxa2 UQCRFS1 UQCRFS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADIPOQAdiponectin, C1Q and collagen domain containing. (247 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (121 aa)
LAMP2Lysosomal associated membrane protein 2. (408 aa)
NDUFB4NADH:ubiquinone oxidoreductase subunit B4. (129 aa)
NDUFA4NDUFA4 mitochondrial complex associated. (82 aa)
CDC42Cell division cycle 42. (191 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
ANXA9Annexin. (345 aa)
GapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (301 aa)
DCNDecorin; May affect the rate of fibrils formation. (361 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1949 aa)
EHD1EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
TOM1Target of myb1 membrane trafficking protein; Belongs to the TOM1 family. (490 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (247 aa)
ANXA13Annexin. (315 aa)
DYSFDysferlin. (2103 aa)
RILPRab interacting lysosomal protein. (363 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (268 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (399 aa)
PLB1Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. (1453 aa)
UQCR10Ubiquinol-cytochrome c reductase, complex III subunit X. (64 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (975 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (475 aa)
ANXA3Annexin. (323 aa)
CYC1Cytochrome c1. (327 aa)
ACP2Acid phosphatase 2, lysosomal; Belongs to the histidine acid phosphatase family. (423 aa)
EEA1Early endosome antigen 1. (1377 aa)
ANXA1Annexin. (346 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (447 aa)
NPPACardiodilatin-related peptide; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (223 aa)
EHD2EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
ANXA11Annexin. (499 aa)
TNNT2Uncharacterized protein. (296 aa)
MAN2B1Lysosomal alpha-mannosidase; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. (1007 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
ANXA6Annexin. (753 aa)
RAB1ARAB1A, member RAS oncogene family. (205 aa)
ANXA5Annexin. (318 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
VPS29Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (209 aa)
LRP1LDL receptor related protein 1. (4508 aa)
ANXA4Annexin. (321 aa)
VAMP8Vesicle associated membrane protein 8. (101 aa)
ACEAngiotensin-converting enzyme. (1302 aa)
LOC100723623Annexin. (327 aa)
ANXA7Annexin. (456 aa)
RAB6ARAB6A, member RAS oncogene family. (192 aa)
GBAGlucosylceramidase. (516 aa)
CANXCalnexin. (593 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (797 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (298 aa)
MYH7BMyosin heavy chain 7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
NDUFB9NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family. (179 aa)
Anxa2Annexin. (339 aa)
UQCRFS1Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (274 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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