STRINGSTRING
PPARG PPARG BCAN BCAN FGF13 FGF13 EMX1 EMX1 NSG2 NSG2 Gapdh Gapdh COX7B COX7B ECHDC2 ECHDC2 RELN RELN TBP TBP SRRM3 SRRM3 Cdk5r2 Cdk5r2 USP9X USP9X BDNF BDNF SLC26A10 SLC26A10 Ywhae Ywhae Vdac1 Vdac1 GPR161 GPR161 NR4A3 NR4A3 Map2 Map2 DLX2 DLX2 NDUFB10 NDUFB10 DACH1 DACH1 FZD9 FZD9 NES NES GLI3 GLI3 STAT3 STAT3 Ndufb8 Ndufb8 WNT3A WNT3A GLUL GLUL Elavl4 Elavl4 DLX1 DLX1 LEF1 LEF1 BTG2 BTG2 AQP4 AQP4 VAMP1 VAMP1 GABRB1 GABRB1 SDHC SDHC SIPA1L3 SIPA1L3 ELAVL2 ELAVL2 Tnip2 Tnip2 TRPC6 TRPC6 NEUROD1 NEUROD1 CHRM4 CHRM4 CHRM1 CHRM1 ACAD11 ACAD11 CRLF1 CRLF1 NDUFA13 NDUFA13 MYL4 MYL4 ZBTB20 ZBTB20 NDUFA3 NDUFA3 C1QL2 C1QL2 SDHB SDHB SPOCK1 SPOCK1 CDK5R1 CDK5R1 Slc4a4 Slc4a4 SRF SRF KCNA3 KCNA3 NDUFAF7 NDUFAF7 LHX5 LHX5 LHX1 LHX1 KLF4 KLF4 SOX5 SOX5 CPT1C CPT1C SATB2 SATB2 NDUFA6 NDUFA6 NDUFB7 NDUFB7 COX7A1 COX7A1 GAD2 GAD2 GPHN GPHN PTPRS PTPRS TTR TTR DOK5 DOK5 KCNC4 KCNC4 ACADSB ACADSB MSI1 MSI1 TRIM67 TRIM67 PLXNA3 PLXNA3 Stmn2 Stmn2 CALB2 CALB2 SDHAF2 SDHAF2 TIAM2 TIAM2 WNT3 WNT3 GABRA4 GABRA4 SLC25A20 SLC25A20 DRD2 DRD2 NDUFA2 NDUFA2 HK2 HK2 Sdha Sdha CUX1 CUX1 ALK ALK SLC1A2 SLC1A2 HDAC1 HDAC1 TGFB2 TGFB2 SLC1A3 SLC1A3 PAX6 PAX6 CAMK4 CAMK4 SYTL2 SYTL2 GABRA1 GABRA1 UQCRC2 UQCRC2 NDUFV1 NDUFV1 DKK3 DKK3 NEUROD6 NEUROD6 MAP1B MAP1B GRIN2B GRIN2B GSX2 GSX2 SLC39A6 SLC39A6 CTTN CTTN GLIS3 GLIS3 HADHB HADHB FGF2 FGF2 KDM6B KDM6B GABRA5 GABRA5 GRIA1 GRIA1 SNAP25 SNAP25 GABRG2 GABRG2 SYT1 SYT1 Ndufa7 Ndufa7 UBA6 UBA6 VIM VIM EGF EGF DCX DCX GRM4 GRM4 GRIK1 GRIK1 NR2E1 NR2E1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
BCANBrevican. (899 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
EMX1Empty spiracles homeobox 1. (258 aa)
NSG2Neuronal vesicle trafficking associated 2. (171 aa)
GapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa)
COX7BCytochrome c oxidase subunit 7B. (80 aa)
ECHDC2Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (292 aa)
RELNReelin. (3423 aa)
TBPTATA-box binding protein. (321 aa)
SRRM3Serine/arginine repetitive matrix 3. (623 aa)
Cdk5r2Uncharacterized protein. (97 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2558 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (289 aa)
SLC26A10Solute carrier family 26 member 10. (668 aa)
Ywhae14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
Vdac1Uncharacterized protein. (283 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (548 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (633 aa)
Map2Microtubule-associated protein. (559 aa)
DLX2Distal-less homeobox 2. (328 aa)
NDUFB10NADH:ubiquinone oxidoreductase subunit B10. (176 aa)
DACH1Dachshund family transcription factor 1. (750 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa)
NESNestin; Belongs to the intermediate filament family. (1712 aa)
GLI3GLI family zinc finger 3. (1580 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
Ndufb8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
GLULGlutamine synthetase. (373 aa)
Elavl4ELAV-like protein; Belongs to the RRM elav family. (385 aa)
DLX1Distal-less homeobox 1. (255 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
VAMP1Vesicle associated membrane protein 1. (118 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (419 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
SIPA1L3Signal induced proliferation associated 1 like 3. (1774 aa)
ELAVL2ELAV-like protein; Belongs to the RRM elav family. (389 aa)
Tnip2EABR domain-containing protein. (430 aa)
TRPC6Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (934 aa)
NEUROD1Neurogenic differentiation factor. (355 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
ACAD11Acyl-CoA dehydrogenase family member 11. (806 aa)
CRLF1Cytokine receptor like factor 1. (420 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (140 aa)
MYL4Myosin light chain 4. (195 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
NDUFA3NADH:ubiquinone oxidoreductase subunit A3. (84 aa)
C1QL2Complement C1q like 2. (287 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (379 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
Slc4a4Anion exchange protein. (1035 aa)
SRFSerum response factor. (461 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (528 aa)
NDUFAF7Protein arginine methyltransferase NDUFAF7; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). (442 aa)
LHX5LIM homeobox 5. (379 aa)
LHX1LIM homeobox 1. (406 aa)
KLF4Kruppel like factor 4. (469 aa)
SOX5SRY-box transcription factor 5. (763 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (807 aa)
SATB2DNA-binding protein SATB. (707 aa)
NDUFA6NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (128 aa)
NDUFB7NADH:ubiquinone oxidoreductase subunit B7. (131 aa)
COX7A1Cytochrome c oxidase subunit 7A1. (80 aa)
GAD2Glutamate decarboxylase 2. (585 aa)
GPHNMolybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (709 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1805 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (131 aa)
DOK5Docking protein 5. (306 aa)
KCNC4Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (594 aa)
ACADSBAcyl-CoA dehydrogenase short/branched chain. (424 aa)
MSI1Musashi RNA binding protein 1. (361 aa)
TRIM67Tripartite motif containing 67. (753 aa)
PLXNA3Plexin A3. (1872 aa)
Stmn2Stathmin; Belongs to the stathmin family. (179 aa)
CALB2Calbindin 2. (271 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (164 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1697 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
GABRA4Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (576 aa)
SLC25A20Solute carrier family 25 member 20; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
NDUFA2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (99 aa)
HK2Hexokinase 2. (917 aa)
SdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (652 aa)
CUX1Cut like homeobox 1. (1421 aa)
ALKTyrosine-protein kinase receptor. (1350 aa)
SLC1A2Amino acid transporter. (573 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
SLC1A3Amino acid transporter. (542 aa)
PAX6Paired box 6. (436 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (418 aa)
SYTL2Synaptotagmin like 2. (923 aa)
GABRA1Gamma-aminobutyric acid type A receptor alpha1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
UQCRC2Ubiquinol-cytochrome c reductase core protein 2; Belongs to the peptidase M16 family. (453 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (347 aa)
NEUROD6Neurogenic differentiation factor. (337 aa)
MAP1BMicrotubule associated protein 1B. (2465 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
GSX2GS homeobox 2. (293 aa)
SLC39A6Solute carrier family 39 member 6. (732 aa)
CTTNCortactin. (550 aa)
GLIS3GLIS family zinc finger 3. (932 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (487 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
KDM6BLysine demethylase 6B. (1467 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (205 aa)
GABRG2Gamma-aminobutyric acid type A receptor gamma2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
SYT1Synaptotagmin 1. (422 aa)
Ndufa7Uncharacterized protein. (113 aa)
UBA6Ubiquitin like modifier activating enzyme 6. (1037 aa)
VIMIF rod domain-containing protein; Belongs to the intermediate filament family. (445 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
DCXDoublecortin. (366 aa)
GRM4Glutamate metabotropic receptor 4. (893 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (934 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (389 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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