STRINGSTRING
ISL1 ISL1 TEAD3 TEAD3 H0V5N2_CAVPO H0V5N2_CAVPO PRKD1 PRKD1 HMGCR HMGCR DENND4C DENND4C OTX2 OTX2 ETV4 ETV4 COL1A1 COL1A1 PAPOLA PAPOLA FASN FASN DLX5 DLX5 GSTO1 GSTO1 TFAP2A TFAP2A LAMP1 LAMP1 CD55 CD55 Egln1 Egln1 AMEL AMEL COL5A1 COL5A1 SERPINH1 SERPINH1 GATA6 GATA6 TAGLN2 TAGLN2 Pou5f1 Pou5f1 ZFP64 ZFP64 RGS2 RGS2 IGFBP3 IGFBP3 S100A16 S100A16 SALL2 SALL2 TIMP3 TIMP3 TDGF1 TDGF1 FABP5 FABP5 IGFBP5 IGFBP5 FURIN FURIN FOXA2 FOXA2 KRT19 KRT19 KCNMA1 KCNMA1 HEY1 HEY1 AGL AGL WNT6 WNT6 STC1 STC1 CLUH CLUH MSX2 MSX2 FZD2 FZD2 SLC7A5 SLC7A5 HSPB8 HSPB8 TRAF3 TRAF3 SFRP2 SFRP2 ESRRB ESRRB TFAP2B TFAP2B DPF3 DPF3 LOC100725073 LOC100725073 APOA1 APOA1 VTCN1 VTCN1 GABRP GABRP AMOTL2 AMOTL2 BMP4 BMP4 PAX6 PAX6 CDX2 CDX2 SLC1A3 SLC1A3 SAMHD1 SAMHD1 GATA3 GATA3 Dab2 Dab2 PTN PTN SDC1 SDC1 WNT11 WNT11 GATA2 GATA2 FOXH1 FOXH1 GRHL1 GRHL1 KRT7 KRT7 TFCP2L1 TFCP2L1 MTOR MTOR PDGFRA PDGFRA AQP3 AQP3 FDPS FDPS NODAL NODAL TFAP2C TFAP2C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ISL1ISL LIM homeobox 1. (349 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (456 aa)
H0V5N2_CAVPOUncharacterized protein. (259 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (845 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
DENND4CDENN domain containing 4C. (1976 aa)
OTX2Orthodenticle homeobox 2. (289 aa)
ETV4ETS variant 4. (464 aa)
COL1A1Collagen type I alpha 1 chain. (1454 aa)
PAPOLAPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (711 aa)
FASNFatty acid synthase. (2530 aa)
DLX5Distal-less homeobox 5. (289 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (239 aa)
TFAP2ATranscription factor AP-2 alpha. (437 aa)
LAMP1Lysosomal associated membrane protein 1. (410 aa)
CD55Complement decay-accelerating factor; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and [...] (446 aa)
Egln1Fe2OG dioxygenase domain-containing protein. (127 aa)
AMELAmelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel (By similarity); Belongs to the amelogenin family. (115 aa)
COL5A1Collagen type V alpha 1 chain. (1822 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (418 aa)
GATA6GATA binding protein 6. (433 aa)
TAGLN2Transgelin; Belongs to the calponin family. (199 aa)
Pou5f1POU domain protein. (361 aa)
ZFP64ZFP64 zinc finger protein. (681 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
IGFBP3Insulin like growth factor binding protein 3. (293 aa)
S100A16Protein S100; Belongs to the S-100 family. (101 aa)
SALL2Spalt like transcription factor 2. (1007 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (169 aa)
FABP5E-FABP; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (796 aa)
FOXA2Forkhead box A2. (459 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (397 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1133 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
AGLAmylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1564 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
STC1Stanniocalcin 1. (247 aa)
CLUHClustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear- encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis; Belongs to the CLU family. (1348 aa)
MSX2Msh homeobox 2. (267 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
SLC7A5Solute carrier family 7 member 5. (477 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
ESRRBEstrogen related receptor beta. (454 aa)
TFAP2BTranscription factor AP-2 beta. (332 aa)
DPF3Double PHD fingers 3. (381 aa)
LOC100725073PID domain-containing protein. (745 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (264 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
GABRPGamma-aminobutyric acid type A receptor pi subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (440 aa)
AMOTL2Angiomotin like 2. (772 aa)
BMP4Bone morphogenetic protein 4. (404 aa)
PAX6Paired box 6. (436 aa)
CDX2Caudal type homeobox 2. (314 aa)
SLC1A3Amino acid transporter. (542 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (526 aa)
GATA3GATA binding protein 3. (443 aa)
Dab2PID domain-containing protein. (766 aa)
PTNPleiotrophin. (168 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (327 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
GATA2GATA binding protein 2. (374 aa)
FOXH1Forkhead box H1. (370 aa)
GRHL1Grainyhead like transcription factor 1. (611 aa)
KRT7Keratin 7; Belongs to the intermediate filament family. (468 aa)
TFCP2L1Transcription factor CP2 like 1. (704 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (352 aa)
NODALNodal growth differentiation factor. (351 aa)
TFAP2CTranscription factor AP-2 gamma. (473 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.