node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HSD11B1 | POMC | ENSCPOP00000005042 | ENSCPOP00000020054 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta- hydroxycholesterol (By similarity). | Corticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. | 0.512 |
INS | LEP | ENSCPOP00000026989 | ENSCPOP00000029200 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.822 |
INS | POMC | ENSCPOP00000026989 | ENSCPOP00000020054 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Corticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. | 0.711 |
INS | UCP1 | ENSCPOP00000026989 | ENSCPOP00000001776 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.578 |
LEP | INS | ENSCPOP00000029200 | ENSCPOP00000026989 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.822 |
LEP | POMC | ENSCPOP00000029200 | ENSCPOP00000020054 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Corticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. | 0.813 |
LEP | UCP1 | ENSCPOP00000029200 | ENSCPOP00000001776 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.627 |
POMC | HSD11B1 | ENSCPOP00000020054 | ENSCPOP00000005042 | Corticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta- hydroxycholesterol (By similarity). | 0.512 |
POMC | INS | ENSCPOP00000020054 | ENSCPOP00000026989 | Corticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.711 |
POMC | LEP | ENSCPOP00000020054 | ENSCPOP00000029200 | Corticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.813 |
SLC1A1 | SLC1A2 | ENSCPOP00000011633 | ENSCPOP00000007025 | Amino acid transporter. | Amino acid transporter. | 0.712 |
SLC1A1 | SLC1A3 | ENSCPOP00000011633 | ENSCPOP00000006730 | Amino acid transporter. | Amino acid transporter. | 0.916 |
SLC1A1 | SLC1A6 | ENSCPOP00000011633 | ENSCPOP00000001896 | Amino acid transporter. | Amino acid transporter. | 0.919 |
SLC1A1 | SLC1A7 | ENSCPOP00000011633 | ENSCPOP00000009609 | Amino acid transporter. | Amino acid transporter. | 0.912 |
SLC1A2 | SLC1A1 | ENSCPOP00000007025 | ENSCPOP00000011633 | Amino acid transporter. | Amino acid transporter. | 0.712 |
SLC1A2 | SLC1A3 | ENSCPOP00000007025 | ENSCPOP00000006730 | Amino acid transporter. | Amino acid transporter. | 0.794 |
SLC1A2 | SLC1A6 | ENSCPOP00000007025 | ENSCPOP00000001896 | Amino acid transporter. | Amino acid transporter. | 0.715 |
SLC1A2 | SLC1A7 | ENSCPOP00000007025 | ENSCPOP00000009609 | Amino acid transporter. | Amino acid transporter. | 0.799 |
SLC1A3 | SLC1A1 | ENSCPOP00000006730 | ENSCPOP00000011633 | Amino acid transporter. | Amino acid transporter. | 0.916 |
SLC1A3 | SLC1A2 | ENSCPOP00000006730 | ENSCPOP00000007025 | Amino acid transporter. | Amino acid transporter. | 0.794 |