Your Input: | |||||
UCP1 | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa) | ||||
PTS | 6-pyruvoyl tetrahydrobiopterin synthase. (145 aa) | ||||
LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa) | ||||
INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa) | ||||
KCNQ2 | Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (871 aa) | ||||
STAT3 | Signal transducer and activator of transcription. (770 aa) | ||||
CCK | Cholecystokinin. (115 aa) | ||||
NTRK2 | Tyrosine-protein kinase receptor. (816 aa) | ||||
POMC | Corticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. (342 aa) | ||||
GHRL | Ghrelin and obestatin prepropeptide. (117 aa) | ||||
MC3R | Melanocortin 3 receptor. (324 aa) | ||||
NPY | Neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa) | ||||
SOCS3 | Suppressor of cytokine signaling 3. (228 aa) | ||||
PYY | Peptide YY. (100 aa) | ||||
SCT | Secretin; Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the p [...] (162 aa) | ||||
GCG | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa) | ||||
JAK2 | Tyrosine-protein kinase. (1035 aa) | ||||
GHSR | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (302 aa) | ||||
TRPC5 | Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa) | ||||
INSR | Tyrosine-protein kinase receptor. (1371 aa) | ||||
TH | Tyrosine hydroxylase. (498 aa) | ||||
AGRP | Agouti related neuropeptide. (132 aa) | ||||
KCNQ3 | Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (860 aa) | ||||
ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa) | ||||
Mc4r | Melanocortin 4 receptor. (333 aa) | ||||
DDC | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. (480 aa) | ||||
BDNF | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (289 aa) | ||||
KCNQ5 | Potassium voltage-gated channel subfamily Q member 5. (908 aa) |