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GATA3 GATA3 NUBP2 NUBP2 ITGA5 ITGA5 CDX2 CDX2 ACKR2 ACKR2 TEAD3 TEAD3 CCNE1 CCNE1 EOMES EOMES BHLHE40 BHLHE40 ITGA3 ITGA3 EGF EGF RXRA RXRA CCR7 CCR7 FGF13 FGF13 RGCC RGCC MUC15 MUC15 TRMT112 TRMT112 ESRRB ESRRB PDCD1 PDCD1 Ccnb1 Ccnb1 B3GNT5 B3GNT5 LGALS1 LGALS1 ALKBH5 ALKBH5 EIF6 EIF6 CD274 CD274 FOXA2 FOXA2 ITGB4 ITGB4 OVOL1 OVOL1 ITGA6 ITGA6 FABP5 FABP5 CD74 CD74 Rps29 Rps29 FMNL2 FMNL2 GCM1 GCM1 ARID3A ARID3A METTL5 METTL5 Muc1 Muc1 LGALS3 LGALS3 ATF3 ATF3 SLC7A8 SLC7A8 TEAD4 TEAD4 EFHD2 EFHD2 RPS28 RPS28 DLX3 DLX3 DSG2 DSG2 LOC100720222 LOC100720222 TIMM50 TIMM50 HAND1 HAND1 CYP26A1 CYP26A1 ITGAV ITGAV CYP19A1 CYP19A1 FLT1 FLT1 ELF5 ELF5 PDGFRA PDGFRA MTOR MTOR CSF3R CSF3R ECM1 ECM1 CDK2 CDK2 LGALS8 LGALS8 GATA2 GATA2 ATP6V0D2 ATP6V0D2 SDC1 SDC1 CCL5 CCL5 TIMMDC1 TIMMDC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GATA3GATA binding protein 3. (443 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (271 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1102 aa)
CDX2Caudal type homeobox 2. (314 aa)
ACKR2Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (417 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (456 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
EOMESEomesodermin. (697 aa)
BHLHE40Basic helix-loop-helix family member e40. (335 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1048 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
RXRARetinoid X receptor alpha. (459 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (375 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
RGCCRegulator of cell cycle. (133 aa)
MUC15Mucin 15, cell surface associated. (319 aa)
TRMT112tRNA methyltransferase subunit 11-2. (132 aa)
ESRRBEstrogen related receptor beta. (454 aa)
PDCD1Programmed cell death 1. (284 aa)
Ccnb1annotation not available (423 aa)
B3GNT5Hexosyltransferase. (377 aa)
LGALS1Galectin. (135 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (246 aa)
CD274CD274 molecule. (289 aa)
FOXA2Forkhead box A2. (459 aa)
ITGB4Integrin beta. (1815 aa)
OVOL1Ovo like transcriptional repressor 1. (253 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1158 aa)
FABP5E-FABP; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
CD74CD74 molecule. (280 aa)
Rps29Uncharacterized protein. (56 aa)
FMNL2Formin like 2. (1091 aa)
GCM1Glial cells missing transcription factor 1. (439 aa)
ARID3AAT-rich interaction domain 3A. (608 aa)
METTL5Methyltransferase like 5. (209 aa)
Muc1SEA domain-containing protein. (640 aa)
LGALS3Galectin. (244 aa)
ATF3Activating transcription factor 3. (181 aa)
SLC7A8Solute carrier family 7 member 8. (535 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (450 aa)
EFHD2EF-hand domain family member D2. (149 aa)
RPS28Ribosomal protein S28. (69 aa)
DLX3Distal-less homeobox 3. (282 aa)
DSG2Desmoglein 2. (985 aa)
LOC100720222Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa)
TIMM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (353 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (963 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1332 aa)
ELF5E74 like ETS transcription factor 5. (255 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CSF3RColony stimulating factor 3 receptor. (842 aa)
ECM1Extracellular matrix protein 1. (562 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
LGALS8Galectin. (316 aa)
GATA2GATA binding protein 2. (374 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (327 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
TIMMDC1Translocase of inner mitochondrial membrane domain containing 1. (283 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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