STRINGSTRING
ENSCPOP00000031348 ENSCPOP00000031348 RHOA RHOA LOC100735260 LOC100735260 S1PR2 S1PR2 SGMS2 SGMS2 TGFB3 TGFB3 RUNX2 RUNX2 LOC100712719 LOC100712719 SPHK2 SPHK2 KDSR KDSR LOC100735813 LOC100735813 STAT3 STAT3 IL17A IL17A ENSCPOP00000023505 ENSCPOP00000023505 ENSCPOP00000023262 ENSCPOP00000023262 Csf1 Csf1 LOC100734419 LOC100734419 S1PR3 S1PR3 CERS6 CERS6 CERK CERK LOC100714182 LOC100714182 H0W5Z7_CAVPO H0W5Z7_CAVPO LOC100735910 LOC100735910 REN REN H0VWU3_CAVPO H0VWU3_CAVPO LOC100712658 LOC100712658 ND4 ND4 PCSK9 PCSK9 ACE2 ACE2 SPHK1 SPHK1 CREB3L1 CREB3L1 CD63 CD63 IL36RN IL36RN IL1F10 IL1F10 TGFB2 TGFB2 MMP9 MMP9 APOE APOE VCAM1 VCAM1 APOB APOB SMPD1 SMPD1 IL1B IL1B ACE ACE CERT1 CERT1 KLF5 KLF5 IL1RN IL1RN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCPOP00000031348Interleukin-1. (182 aa)
RHOARas homolog family member A. (193 aa)
LOC100735260Interleukin-1. (160 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RUNX2RUNX family transcription factor 2. (541 aa)
LOC100712719Interleukin-1. (163 aa)
SPHK2Sphingosine kinase 2. (655 aa)
KDSR3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
LOC100735813Interleukin-1. (160 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL17AUncharacterized protein. (158 aa)
ENSCPOP00000023505Interleukin-1. (182 aa)
ENSCPOP00000023262Interleukin-1. (137 aa)
Csf1Uncharacterized protein. (257 aa)
LOC100734419Interleukin-1. (150 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (373 aa)
CERS6Ceramide synthase 6. (392 aa)
CERKCeramide kinase. (483 aa)
LOC100714182Angiotensin-converting enzyme. (701 aa)
H0W5Z7_CAVPOAngiotensin-converting enzyme. (622 aa)
LOC100735910Angiotensin-converting enzyme. (706 aa)
RENRenin; Belongs to the peptidase A1 family. (403 aa)
H0VWU3_CAVPOAngiotensin-converting enzyme. (685 aa)
LOC100712658Angiotensin-converting enzyme. (718 aa)
ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (459 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (686 aa)
ACE2Angiotensin-converting enzyme. (794 aa)
SPHK1Sphingosine kinase 1. (386 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (522 aa)
CD63Tetraspanin. (238 aa)
IL36RNInterleukin-1. (156 aa)
IL1F10Interleukin-1. (149 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
MMP9Matrix metallopeptidase 9. (715 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (298 aa)
VCAM1Vascular cell adhesion molecule 1. (732 aa)
APOBApolipoprotein B. (4479 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
ACEAngiotensin-converting enzyme. (1302 aa)
CERT1Ceramide transporter 1. (564 aa)
KLF5Kruppel like factor 5. (374 aa)
IL1RNInterleukin-1. (176 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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