STRINGSTRING
PLA2G4F PLA2G4F ASAH1 ASAH1 GOT1 GOT1 UGCG UGCG NEU2 NEU2 GALC GALC ASAH2 ASAH2 SPHK2 SPHK2 Gapdh Gapdh SMPD3 SMPD3 ACER3 ACER3 SMPD4 SMPD4 S1PR2 S1PR2 ACER2 ACER2 SGMS2 SGMS2 SAMD8 SAMD8 CERS2 CERS2 GBA2 GBA2 SPTLC1 SPTLC1 CERS4 CERS4 CERK CERK S1PR3 S1PR3 SGPP1 SGPP1 SGPL1 SGPL1 IL1B IL1B GOT2 GOT2 ACTB ACTB SGPP2 SGPP2 SMPD2 SMPD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLA2G4FPhospholipase A2. (842 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa)
GOT1Aspartate aminotransferase. (413 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (393 aa)
NEU2Neuraminidase 2. (381 aa)
GALCGalactosylceramidase. (685 aa)
ASAH2Neutral ceramidase. (752 aa)
SPHK2Sphingosine kinase 2. (655 aa)
GapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (823 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
SAMD8Sterile alpha motif domain containing 8. (415 aa)
CERS2Ceramide synthase 2. (380 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (908 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (461 aa)
CERS4Ceramide synthase 4. (391 aa)
CERKCeramide kinase. (483 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (373 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (407 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
GOT2Aspartate aminotransferase. (430 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (354 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (430 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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